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US 6,544,543 B1Granted
Periodic constriction of vessels to treat ischemic tissue
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsEvgenia Mandrusov, Christopher J. Buchko, Wouter E. Roorda
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Abstract
Brief periods of occlusion of blood flow in an otherwise open target vessel adjacent to vessels supplying blood to an ischemic region are caused by periodic administration of a therapeutically effective amount of a vasoconstrictor. It is anticipated these brief periods of occlusion will induce the enlargement of collateral vessels, causing increased blood flow to the ischemic region.
Claims15
A method for treating ischemia in a patient, the method comprising:
- depositing a layer of polymer on the luminal surface of a target vessel;
- and
- injecting microspheres containing a vasoconstrictor into the patient, wherein the microspheres are adapted to attach to the layer of polymer and release the vasoconstrictor in situ adjacent to the layer of polymer.
Dependencies are inferred from the claim text.