Diabetes management system
AssigneeRoche Diagnostics GmbH
InventorsPaul J. Galley, Ajay Thukral, Siva K. Chittajallu, Stefan Weinert
Life of this patent
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Abstract
A system is provided that enables glycemic control for a subject. The system includes an insulin delivery unit, a glucose sensor, and a control unit. The control unit includes a processor unit that receives glucose value readings from the glucose sensor, executes an algorithm that predicts a glucose value at a predetermined time in the future, compares that predicted glucose value to a pre-determined glucose value range, and determines a corrective amount of insulin to be administered when the predictive glucose value lies outside of the predetermined glucose value range. The control unit also includes a communication unit that transmits the corrective amount to the delivery unit.
Claims25
A system for providing glycemic control to a subject, the system comprising:
- an insulin delivery unit,
- a glucose sensor, and
- a control unit including a processor unit that receives glucose value readings from the glucose sensor, executes an algorithm that predicts a glucose value at a pre-determined time in the future, compares that predicted glucose value to a pre-determined glucose value range, and determines a corrective amount of insulin to be administered when the predictive glucose value lies outside of the pre-determined glucose value range and a communication unit that transmits the corrective amount to the delivery unit.
A system for providing glycemic control to a subject comprising:
- a sensor formed to conduct a glucose measurement of a subject,
- a control unit including a processor unit that is formed to accept data from the subject on insulin sensitivity and basal rate, to execute an algorithm that generates a predictive value of the subject's glucose level at a predetermined time in the future based upon the glucose measurement from the sensor and the data, and to compute a corrective action when the predictive value lies outside of a predetermined target range, and
- an insulin delivery unit in communication with the control unit, the delivery unit being formed to administer automatically a dosage of insulin to the subject based upon the computed corrective action of the control unit.
A method for providing glycemic control to a subject, the method comprising the steps of:
- determining the glucose value of a subject,
- inputting the glucose value into at least one processor, the at least one processor being formed to execute at least one algorithm formed to anticipate the future effects of insulin that has been previously delivered to the subject, to incorporate constraints on insulin delivery and glucose deviations, and to determine a corrective amount of insulin to be administered when the predictive glucose value lies outside of the pre-determined glucose value range,
- automatically delivering the corrective amount of insulin to the subject, and
- repeating the determining and inputting steps.
A system for providing glycemic control to a subject, the system comprising:
- means for delivering insulin to a subject,
- means for determining a glucose value from the subject, and
- a control unit including a processor unit that is formed to compare the glucose value to a pre-determined glucose value range, to determine a corrective amount of insulin to be administered when the predictive glucose value lies outside of the pre-determined glucose value range, and to transmit the corrective amount to the delivering means.
A system for predicting a future glucose value of a subject at a predetermined time, the system comprising a control unit that comprises:
- a processor unit formed to predict the future glucose value with an algorithm
- ΔG=—(TotallnsuRemain—BasalReq) * Sensitivity wherein ΔG=future change in glucose levels at a pre-determined time, TotallnsuRemain=amount of insulin remaining in the subject's system at a current time, and BasalReq=how much insulin the subject is estimated to need to maintain the current glucose level, and Sensitivity=Insulin sensitivity, and
- wherein the processor makes a recommended insulin dose to reach a target range in full time of the insulin action according to the following equation:
- InsuRecommend=[G(0)+ΔG−Target]/Sensitivity+BasalNeed PerCycle
- wherein InsuRecommend=recommended insulin dosage, G (0)=predicted current glucose level, Target=glucose target level, and BasalNeed PerCycle=basal requirements of the subject during each cycle.
A system for recommending an insulin dose to compensate for meals of a subject, the system comprising a control unit that comprises:
- a processor formed to compensate for meals with a feedforward algorithm
- Dose=carbohydrates * insulin-to-carb-ratio * αmeal type—intercept
- wherein Dose=Total insulin dose, carbohydrates=grams of carbohydrates, insulin-to-carb-ratio=Insulin to Carbohydrate Ratio, αmeal type=meal dependent scaling factor, and intercept to allow a linear fit for sizes of the meals.
The system of claim 25 wherein the processor is further formed to provide a constraint to the feedforward algorithm, wherein the constraint is defined by the following equation:
- infusion rate ≳β* basal rate, wherein β=a fraction that defines a minimum basal rate.
Dependencies are inferred from the claim text.