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US 6,541,669 B1Granted
β2-adrenergic receptor agonists
AssigneeTheravance, Inc.
InventorsEdmund J. Moran, Seok-Ki Choi
Life of this patent
Estimating the term…
Abstract
Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.
Claims23
A compound of Formula (II):
- wherein
- Ar1 and Ar3 are independently selected from the group consisting of aryl, heteroaryl and heterocyclyl;
- Ar2 is selected from the group consisting of (a) phenylene, wherein W and X are attached at the 1,2-, 1,3- and 1,4-positions of the phenylene ring;
- (b) cyclohexylene optionally substituted with methyl, wherein W and X are attached at the 1,3- and 1,4-positions of the cyclohexylene ring;
- and piperazinylene, wherein W and X are attached at the 1,4-positions of the piperazinylene ring;
- Q is —NHCH2CH(OH)—;
- W is alkylene or substituted alkylene;
- X is a covalent bond;
- and pharmaceutically acceptable salts thereof.
6 more elements
A compound of Formula (II):
- wherein
- Ar1 is selected from the group consisting of aryl, heteroaryl and heterocyclyl;
- Ar2 is 1,4-phenylene;
- Ar3 is selected from the group consisting of:
- Q is —NHCH2CH(OH)—;
- W is methylene, ethylene or propylene;
- X is a covalent bond;
- and pharmaceutically acceptable salts thereof.
5 more elements
A compound of the formula:
- and pharmaceutically acceptable salts thereof.
A compound of the formula:
- and pharmaceutically acceptable salts thereof.
A compound of the formula:
- and pharmaceutically acceptable salts thereof.
A compound of the formula:
- and pharmaceutically acceptable salts thereof.
A compound of the formula:
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.