Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device

A method of coating an intracorporeal medical device, comprising:

• a) applying to the medical device a grafting component and a binding component, wherein the grafting component is selected from the group consisting of vinyl, acrylate and allyl compounds, and the binding component has at least a first functional group selected from the group consisting of isocyanate, aldehyde, oxirane, succinimide, maleimide, acetoacetoxy, aziridine, carboxy, and carbodiimide;
• b) polymerizing the grafting component, so that the grafting component adheres to the device and bonds the binding component thereto, to form a base coat on the device;
• and
• c) applying to the base coat a top coat having an agent selected from the group consisting of superoxide dismutase and a superoxide dismutase mimic, to covalently bond the agent to the binding component.

A method of treating a patient, comprising introducing into the patient a medical device having a coating on at least a section of the device, the coating comprising

• a) a polymerized base coat on the device, comprising:
• a binding component having at least a first functional group selected from the group consisting of isocyanate, aldehyde, oxirane, succinimide, maleimide, acetoacetoxy, aziridine, and carbodiimide;
• and
• a grafting component selected from the group consisting of vinyl, acrylate and allyl compounds, adhered to the device and bonded to the binding component;
• and
• b) a top coat on the base coat, comprising an agent selected from the group consisting of superoxide dismutase and a superoxide dismutase mimic, or a complex of the agent and a linking agent, the agent or the linking agent having a functional group which bonds with the binding component.

A method of providing a coating for an intracorporeal medical device, comprising:

• a) applying to the medical device a solution having a grafting component and a binding component, wherein the grafting component is selected from the group consisting of vinyl, acrylate and allyl compounds, and the binding component is selected from the group consisting of polyaziridine compounds, polycarbodiimide compounds, aldehyde compounds, and isocyanate compounds;
• b) polymerizing the grafting component in the presence of the binding component by irradiating the grafting component with radiation, and bonding the grafting component to the binding component, to form a base coat on the device;
• and
• c) applying to the base coat a solution of a top coat compound comprising an agent selected from the group consisting of superoxide dismutase and a superoxide dismutase mimic, or a complex of the agent and a linking agent, the agent or the linking agent having a functional group which bonds with the binding component, so that the top coat compound bonds to the binding component, to form the coating on the medical device.

An intracorporeal medical device having a coating, the coating comprising:

• a) a polymerized base coat on the device formed from a solution of a binding component and a grafting component polymerized and crosslinked to the binding component on the device so that the grafting component bonds to the device,
• i) the binding component being selected from the group consisting of polyaziridine compounds, polycarbodiimide compounds, aldehyde compounds, and isocyanate compounds and
• ii) the grafting component being selected from the group consisting of vinyl, acrylate and allyl compounds;
• and
• b) a top coat on the base coat, comprising an agent selected from the group consisting of superoxide dismutase and a superoxide dismutase mimic, or a complex of the agent and a linking agent, the agent or the linking agent having a functional group which bonds with the binding component and which is selected from the group consisting of carboxyl groups, hydroxy groups and amine groups, bonded to the binding component.