Regeneration and augmentation of bone using mesenchymal stem cells
AssigneeOsiris Therapeutics, Inc.
InventorsSudhakar Kadiyala, Scott P. Bruder
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Abstract
Disclosed are compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) with a ceramic material or matrix or by administering hMSCs; fresh, whole marrow; or combinations thereof in a resorbable biopolymer which supports their differentiation into the osteogenic lineage. Contemplated is the delivery of (i) isolated, culture-expanded, human mesenchymal stem cells; (ii) freshly aspirated bone marrow; or (iii) their combination in a carrier material or matrix.
Claims16
A method of augmenting bone formation in an individual in need thereof by administering to said individual isolated human mesenchymal stem cells with a resorbable biopolymer selected from the group consisting of a gelatin, collagen, and cellulose, wherein said resorbable biopolymer supports the differentiation of such stem cells into the osteogenic lineage to an extent sufficient to generate bone formation therefrom.
A composition for augmenting bone formation, said composition comprising a resorbable biopolymer selected from the group consisting of gelatin, cellulose, and collagen, in combination with isolated mesenchymal stem cells.
A composition for augmenting bone formation, said composition comprising a resorbable biopolymer selected from the group consisting of gelatin, cellulose, and collagen, wherein said resorbable biopolymer is a sponge, strip, film, gel, or web, or a structurally stable, three dimensional implant, in combination with isolated mesenchymal stem cells.
A method for augmenting bone formation in an individual in need thereof which comprises administering to said individual a composition comprising a resorbable biopolymer selected from the group consisting of gelatin, cellulose, and collagen in combination with isolated mesenchymal stem cells.
Dependencies are inferred from the claim text.