Mineral and cellular patterning on biomaterial surfaces
AssigneeThe Regents of the University of Michigan
InventorsWilliam L. Murphy, David J. Mooney, David H. Kohn, Gabriel C. Spalding, Matthew T. Dearing
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Abstract
Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces. Also provided are various methods of using the mineralized and/or patterned biomaterials in tissue engineering, such as bone tissue engineering, providing more control over ongoing biological processes, such as mineralization, growth factor release, cellular attachment and tissue growth.
Claims79
A method for generating a patterned surface on a biocompatible material, comprising irradiating at least a first photosensitive surface of a biocompatible material with pre-patterned electromagnetic radiation in the form of constructively and destructively interfering electromagnetic radiation, thereby generating a pattern on said at least a first surface of said biocompatible material.
Dependencies are inferred from the claim text.