Encapsulated cells producing cytochrome P450

A method of treating a solid tumor comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows cyclophosphamide to pass into the capsule and, either simultaneously or with a time span, administering the cyclophosphamide which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.

A method of treating a solid tumor comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows ifosfamide to pass into the capsule and, either simultaneously or with a time span, administering the ifosfamide which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.

A method of treating a pancreatic solid tumor comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows prodrug molecules to pass into the capsule and, either simultaneously or with a time span, administering a prodrug which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.

A method of treating a pancreatic solid tumor comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows cyclophosphamide to pass into the capsule and, either simultaneously or with a time span, administering the cyclophosphamide which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.

A method of treating a pancreatic solid tumor comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows ifosfamide to pass into the capsule and, either simultaneously or with a time span, administering the ifosfamide which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.

A method of treating a solid tumor in a breast comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows prodrug molecules to pass into the capsule and, either simultaneously or with a time span, administering a prodrug which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.

A method of treating a solid tumor in a breast comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows cyclophosphamide to pass into the capsule and, either simultaneously or with a time span, the cyclophosphamide which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.

A method of treating a solid tumor in a breast comprising locally administering into the tumor or close to a site of the tumor to a subject in need thereof, a therapeutically effective amount of a capsule encapsulating cytochrome P450 producing cells, said capsule comprising a porous membrane which protects the cells from the immune system and allows ifosfamide to pass into the capsule and, either simultaneously or with a time span, the ifosfamide which is activated by cytochrome P450, wherein solid tumor mass is reduced when compared to the solid tumor mass prior to said administration.