Polypeptide variants
AssigneeGenentech, Inc.
InventorsEsohe Ekinaduese Idusogie, Leonard G. Presta, Michael George Mulkerrin
Life of this patent
Estimating the term…
Abstract
Isolated nucleic acid, vectors and host cells encoding antibody or immunoadhesin variants, as well as a process for producing the variants. The variants comprise a human IgG Fc region with amino acid substitution(s) therein, and display altered C1q binding function.
Claims20
An isolated nucleic acid encoding an antibody variant which binds antigen or an immunoadhesin variant which binds a ligand or receptor, the antibody or immunoadhesin variant comprising a human IgG Fc region comprising an amino acid substitution at amino acid position 329, or at two or all of amino acid positions 329, 331 and 322 of the human IgG Fc region, where the numbering of the residues in the IgG Fc region is that of the EU index as in Kabat.
An isolated nucleic acid encoding an antibody variant which binds antigen or an immunoadhesin variant which binds a ligand or receptor, the antibody or immunoahesin variant comprising a human IgG Fc region comprising an amino acid substitution at amino acid position 322 or amino acid position 329, or both amino acid positions of the human IgG Fc region, where the numbering of the residues in the IgG Fc region is that of the EU index as in Kabat.
Dependencies are inferred from the claim text.