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US 6,537,785 B1Granted
Methods of treating lysosomal storage diseases
AssigneeGenzyme Glycobiology Research Institute, Inc.
InventorWilliam M. Canfield
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Abstract
The present invention provides methods of treating lysosomal storage disease with highly phosphorylated lysosomal hyrdrolases.
Claims10
a method of treating a patient suffering from Pompe's disease comprising
- administering to a patient in need thereof, a composition comprising human recombinant α-glucosidase, wherein the composition has an average of at least 5 mannose 6-phosphates per human recombinant α-glucosidase and a pharmaceutically acceptable carrier, in an amount sufficient to treat said disease.
A method of treating a patient suffering from Pompe's disease comprising
- administering to a patient in need thereof, a composition comprising human recombinant α-glucosidase, wherein the composition has an average of about at least 6% bis-phosphorylated oligosaccharides per human recombinant α-glucosidase and a physiologically acceptable carrier, in an amount sufficient to treat said disease.
Dependencies are inferred from the claim text.