Methods for encapsulating plasmids in lipid bilayers
AssigneeInex Pharmaceuticals Corporation
InventorsJeffery J. Wheeler, Michael Hope, Pieter R. Cullis, Marcel B. Bally
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Abstract
Plasmid-lipid particles which are useful for transfection of cells in vitro or in vivo are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. The particles are typically 65-85 nm, fully encapsulate the plasmid and are serum-stable.
Claims18
A nucleic acid-lipid particle for introducing a nucleic acid into a cell, said particle comprising a cationic lipid, a non-cationic lipid, and a nucleic acid, wherein said nucleic acid in said nucleic acid-lipid particle is resistant in aqueous solution to degradation by a nuclease.
Dependencies are inferred from the claim text.