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US 6,534,041 B1Granted
Acid-labile and enzymatically divisible dye compounds for diagnosis with near infrared light and for therapy
AssigneeInstitute for Diagnostic Research GmbH of the Free University of Berlin
InventorsKai Licha, Bjorn Riefke, Wolfhard Semmler, Wolfgang Wrasidlo
Life of this patent
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Abstract
The invention relates to acid-labile and enzymatically divisible compounds for in-vivo and in-vitro diagnosis by means of near infrared radiation (NIR-radiation), the use of said compounds as optic diagnostic and therapeutic agents, and the diagnostic agents containing said compounds.
Claims13
A compound of general formula I
- (F—L)m—A (I),
- where
- F is a cyanine, squarilium, croconium, merocyanine or oxonol dye molecule with at least one absorption maximum of between 600 and 1200 nm,
- L is a linker structure which contains —C═N— and contains an acid-labile bond,
- m is a number between 1 and 80,
- whereby if m is a number between 1 and 3,
- A is a dye molecule with at least one absorption maximum of between 600 and 1200 nm, an antibiotically or anticytostatically active molecule, a biomolecule, a non-biological macromolecule or a compound B—(L—W)o or D—(L—W)o, whereby
- D is a non-biological macromolecule,
- B is a biomolecule,
- L independently has the above-mentioned meaning,
- W is an antibiotically or anticytostatically active molecule,
- o is a number between 1 and 20,
- and whereby if m is number between 4 and 80,
- A is a biomolecule, a non-biological macromolecule or a compound B—(L—W)o or D—(L—W)o, whereby
- D, B, L, W and o have the above-mentioned meanings.
12 more elements
A compound of general formula I
- (F—L)m—A (I),
- where
- F is a cyanine, squarilium, croconium, merocyanine or oxonol dye molecule with at least one absorption maximum of between 600 and 1200 nm
- L is a linker structure which contains —C═N— and contains an enzymatically cleavable bond,
- m is a number between 1 and 80,
- whereby if m is a number between 1 and 3,
- A is a dye molecule with a least one absorption maximum of between 600 and 1200 nm, an antibiotically or anticytostatically active molecule, a biomolecule, a non-biological macromolecule or a compound B—(L—W)o or D—(L—W)o, whereby
- D is a non-biological macromolecule,
- B is a biomolecule,
- L independently has the above-mentioned meaning,
- W is an antibiotically or anticytostatically active molecule,
- o is a number between 1 and 20,
- and whereby if m is number between 4 and 80,
- A is a biomolecule, a non-biological macromolecule or a compound B—(L—W)o or D—(L—W)o, whereby
- D, B, L, W and o have the above-mentioned meanings.
12 more elements
Dependencies are inferred from the claim text.