Back to results
US 6,533,936 B1Granted
Method for separation of optical isomers
AssigneeDaicel Chemical Industries, Ltd.
InventorHirokazu Ikeda
Life of this patent
Estimating the term…
Abstract
The method of separation of optical isomers in accordance with the present invention is directed to providing a method of separation of optical isomers which enables efficient optical resolution of optical isomer mixture not using expensive silica gel but using a filler which is inexpensive per se and has excellent optical resolution ability, and characterized in that particles of polysaccharide derivatives, preferably ester derivatives and carbamate derivatives of polysaccharide are used as an optical resolution filler.
Claims11
A method of separation of optical isomers using a simulated moving bed chromatographic apparatus which comprises:
- forming a circulation circuit comprising a plurality of columns each provided with an inlet port and an outlet port and packed with particles of polysaccharide derivatives, said columns being serially and endlessly connected so as to achieve serial and unidirectional fluid flow through said columns, wherein the particles of polysaccharide derivatives are not supported on a silica gel carrier;
- introducing an optical isomer mixture to be separated into one of the columns via the inlet port thereof in order to cause adsorbable or strongly adsorbable substances to become adsorbed on the particles of polysaccharide derivatives in the column and several columns that follow;
- drawing out a solution rich in the other substances being non-adsorbable or poorly adsorbable on the particles of polysaccharide derivatives via the outlet port of another one of the columns;
- introducing an eluent into still another one of the columns via the inlet port thereof;
- drawing out a solution rich in the adsorbable or strongly adsorbable substances via the outlet port of further another one of the columns;
- and
- passing the remaining solution and the eluent through the circuit and recirculating them,
- wherein the position for introducing the eluent, the position for drawing out the solution containing the adsorbable or strongly adsorbable substances, the position for introducing the optical isomer mixture and the position for drawing out the solution containing the non-adsorbable or weakly adsorbable substances are arranged in the circulation in this order along the direction of the fluid flow, and the positions are successively moved in the direction of the fluid flow in the circuit intermittently.
5 more elements
In a method of separation of optical isomers using a simulated moving bed chromatographic apparatus which comprises:
- forming a circulation circuit comprising a plurality of columns each provided with an inlet port and an outlet port and packed with an optical resolution filler, said columns being serially and endlessly connected so as to achieve serial and unidirectional fluid flow through said columns;
- introducing an optical isomer mixture to be separated into one of the columns via the inlet port thereof in order to cause adsorbable or strongly adsorbable substances to become adsorbed on the optical resolution filler in the column and several columns that follow;
- drawing out a solution rich in the other substances being non-adsorbable or poorly adsorbable on the optical resolution filler via the outlet port of another one of the columns;
- introducing an eluent into still another one of the columns via the inlet port thereof;
- drawing out a solution rich in the adsorbable or strongly adsorbable substances via the outlet port of further another one of the columns;
- and
- passing the remaining solution and the eluent through the circuit and recirculating them,
- wherein the position for introducing the eluent, the position for drawing out the solution containing the adsorbable or strongly adsorbable substances, the position for introducing the optical isomer mixture and the position for drawing out the solution containing the non-adsorbable or weakly adsorbable substances are arranged in the circulation in this order along the direction of the fluid flow, and the positions are successively moved in the direction of the fluid flow in the circuit intermittently, the improvement which comprises using particles of polysaccharide derivatives as the optical resolution filler, wherein the particles of polysaccharide derivatives are not supported on a silica gel carrier.
5 more elements
Dependencies are inferred from the claim text.