# US 6,533,821 B1 · Bio-adhesive composition, method for adhering objects to bone

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- Number: US 6,533,821 B1
- Document ID: US6533821B1
- Status: Granted
- Kind: B1
- Application number: 09/602,067
- Filed: 2000-06-22
- Granted: 2003-03-18
- Earliest claimed: 2000-06-22
- Inventors: Thomas Lally
- Web page: https://patentgrep.com/patent/US6533821B1

## CPC

- A61F 2/28: Bones
- A61L 24/02: containing inorganic materials
- C04B 28/34: containing cold phosphate binders
- A61B 17/00491: {Surgical glue applicators}
- A61F 2/0811: {Fixation devices for tendons or ligaments}
- A61F 2002/30062: {(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive}
- A61F 2002/4649: {Bone graft or bone dowel harvest sites}
- A61F 2210/0004: bioabsorbable
- A61F 2310/00011: Metals or alloys
- A61F 2310/00179: Ceramics or ceramic-like structures
- A61F 2310/00185: based on metal oxides
- A61F 2310/00197: containing magnesia or magnesium oxide
- A61F 2310/00293: containing a phosphorus-containing compound, e.g. apatite
- C04B 2111/00836: {for medical or dental applications}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C04B: LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE {(roofing granules E04D7/005)}; CERAMICS (devitrified glass-ceramics C03C10/00); REFRACTORIES; TREATMENT OF NATURAL STONE
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The invention provides for a bio-adhesive derived from a mixture comprising KH2PO4, a metal oxide, a calcium-containing compound, and water. Also provided is a reabsorbable bone substitute derived from a mixture comprising KH2PO4 and an oxide in a 1:1 weight percent ratio, a calcium-containing compound, and water.

## Claims

### Claim 1

A bio-adhesive comprising:
a) means for attaching objects to bone;
b) means for enhancing said attachment means; and
c) means for facilitating in vivo degradation of the bio-adhesive,
wherein said bio-adhesive is derived from a mixture of KH2PO4, metal oxide, a calcium compound, and water and the weight percent ratio of KH2PO4 and the oxide ranges from between approximately 1:0.5 and 1:1.

### Claim 2 (depends on 1)

The bio-adhesive as recited in claim 1 wherein the objects are manmade materials selected from the group consisting of metal, composite, ceramic, and combinations thereof.

### Claim 3 (depends on 1)

The bio-adhesive as recited in claim 1 wherein the objects are biological materials selected from the group consisting of ligaments, tendons, bone, teeth, and blood vessels.

### Claim 4 (depends on 1)

The bio-adhesive as recited in claim 1 wherein the enhancement means is the ability of the bio-adhesive to expand in vivo during setting.

### Claim 5 (depends on 1)

The bio-adhesive as recited in claim 1 wherein the oxide is calcinated.

### Claim 6 (depends on 1)

The bio-adhesive as recited in claim 1 wherein the calcium compound is Ca10(PO4)6(OH)2.

### Claim 7

A bio-adhesive comprising:
a) means for attaching objects to bone;
b) means for enhancing said attachment means; and
c) means for facilitating in vivo degradation of the bio-adhesive,
wherein said bio-adhesive is derived from a mixture of KH2PO4, metal oxide wherein the metal oxide is MgO, a calcium compound, and water and the weight percent ratio of KH2PO4 and MgO is 1:1.