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US 6,528,640 B1Granted
Synthetic ribonucleic acids with RNAse activity
AssigneeRibozyme Pharmaceuticals, Inc.
InventorsLeonid Beigelman, Alex Burgin, Amber Beaudry, Alexander Karpeisky, Jasenka Matulic-Adamic, David Sweedler, Shawn Zinnen
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Abstract
Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g., ribozymes) are disclosed. Also, described are the use of novel enzymatic nucleic acid molecules to inhibit HER2/neu/ErbB2 gene expression and their applications in human therapy.
Claims3
An enzymatic nucleic acid molecule having formula II:
- wherein each X, Y, and Z represents independently a nucleotide which may be the same or different;
- q is an integer ranging from 3 to 100;
- m is an integer ranging from 1 to 10;
- n is an integer ranging from 1 to 10;
- o is an integer ranging from 3 to 100;
- Z′ is a nucleotide complementary to Z;
- Y′ is a nucleotide complementary to Y;
- each X(q) and X(o) are oligonucleotides which are of sufficient length to stably interact independently with a target nucleic acid sequence;
- W is a linker ranging from 2 to 70 nucleotides;
- A, U, G, and C represent nucleotides;
- C is 2′-deoxy-2′-amino cytidine;
- and _ represents a chemical linkage.
9 more elements
An enzymatic nucleic acid molecule having formula III namely:
- wherein each X, Y, and Z represents independently a nucleotide which may be the same or different;
- q is an integer ranging from 3 to 100;
- m is an integer ranging from 1 to 10;
- n is an integer ranging from 1-10;
- o is an integer ranging from 3-100;
- Z′ is a nucleotide complementary to Z;
- Y′ is a nucleotide complementary to Y;
- each X(q) and X(o) are oligonucleotides which are of sufficient length to stably interact independently with a target nucleic acid sequence;
- W is a linker ranging from 2 to 70 nucleotides;
- A, U, G, and C represent nucleotides;
- C 2′-deoxy-2′-aminocytidine;
- and _ represents a chemical linkage.
9 more elements
Dependencies are inferred from the claim text.