Ligands for metabotropic glutamate receptors and inhibitors of NAALADase

A compound represented by structure 1:

• wherein
• X is selected from the group consisting of —C(O)—, —C(S)—, —S(O)2—, —C(R)(OR)—, and —C(R)(SR)—;
• Y is selected, independently for each occurrence, from the group consisting of (CR2)n, (NR)n, and a bond;
• Z is selected, independently for each occurrence, from the group consisting of C(R), C(NR2), and C(NHacyl);
• W is selected, independently for each occurrence, from the group consisting of (CR2)m, (NR)m, and a bond;
• G is selected, independently for each occurrence, from the group consisting of H, —COOH, —SO3H, —P(O)(OH)2, —SR, and 2-R-tetrazol-5-yl;
• R is selected, independently for each occurrence, from the group consisting of H, alkyl, heteroalkyl, aryl, heteroaryl, and aralkyl;
• and also including a negative charge for instances of R bonded to a heteroatom;
• m and n are integers selected, independently for each occurrence, from the range 0 to 3 inclusive;
• and
• the stereochemical configuration at any stereocenter of a compound represented by 1 is R, S, or a mixture of these configurations.