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US 6,528,486 B1Granted
Peptide agonists of GLP-1 activity
AssigneeZealand Pharma A/S
InventorsBjarne Due Larsen, Jens Damsgaard Mikkelsen, Søren Neve
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel peptide conjugates which have increased stability and are useful in the treatment of excess levels of blood glucose.
Claims2
A peptide consisting of any one of the following sequences:
- a) H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-(Lys)6-NH2 (des-Pro36-exendin-4(1-39)-Lys6-NH2) (SEQ ID NO:93),
- b) H-Lys6-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-(Lys)6-NH2 (H-Lys6-des Pro36exendin-4(1-39)-Lys6-NH2) (SEQ ID NO:
- 149),
- c) H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-NH2 (H-des Pro36,Pro37,Pro38exendin-4(1-39)-NH2) (SEQ ID NO:
- 132),
- d) H-Lys-Lys-Lys-Lys-Lys-Lys-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-NH2 (H-(Lys)6-des Pro36,Pro37,Pro38exendin-4(1-39)-NH2), (SEQ ID NO:
- 134),
- e) H-Asn-Glu-Glu-Glu-Glu-Glu-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-NH2 (H-Asn-(Glu)5-des Pro36,Pro37, Pro38exendin-4(1-39)-NH2) (SEQ ID NO:
- 137),
- f) H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-(Lys)6-NH2 (des Pro36, Pro37,Pro38exendin-4(1-39)-(Lys)6-NH2) (SEQ ID NO:
- 133),
- g) H-(Lys)6-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-(Lys)6-NH2 (H-(Lys)6-des Pro36,Pro37,Pro38exendin-4(1-39)-(Lys)6-NH2) (SEQ ID NO:
- 135),
- h) H-Asp-Glu-Glu-Glu-Glu-Glu-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Ser-(Lys)6-NH2 (H-Asn-(Glu)5-des Pro36,Pro37,Pro38exendin-4(1-39)-(Lys)6-NH2) (SEQ ID NO:
- 136);
- or a pharmaceutically acceptable salt thereof.
13 more elements
Dependencies are inferred from the claim text.