Myeloid cell leukemia associated gene MCL-1
AssigneeDartmouth College
InventorRuth W. Craig
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Abstract
A gene, mc1-1, of the bc1-2 family is disclosed along with its nucleotide and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of utilizing the mc1-1 nucleotide and polypeptide sequences.
Claims8
A method for identifying a cell expressing an mcl-1 polypeptide, the method comprising contacting a nucleic acid component of the cell with a poly nucleotide reagent that binds to the nucleic acid component, wherein the nucleic acid component comprises a polynucleotide encoding SEQ ID NO:2 or a fragment comprising at least 15 nucleotides of said polynucleotide, and detecting specific binding of the reagent, thereby identifying a cell expressing an mcl-1 polypeptide.
Dependencies are inferred from the claim text.