Biodegradable polymer composition
AssigneeAtrix Laboratories, Inc.
InventorsRichard L Dunn, James P. English
Life of this patent
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Abstract
A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.
Claims34
A pharmaceutical system suitable for forming a biodegradable article for use in a body, the pharmaceutical system comprising:
- a flowable composition of a biocompatible, biodegradable, branched, thermoplastic polymer that is at least substantially insobule in aqueous medium, water, or body fluid;
- and a biocompatible organic solvent that is at least slightly soluble in aqueous medium, water, or body fluid;
- wherein the polymer is selected from the group consisting of polyamides, polyurethanes, polyureas, copolymers, terpolymers, combinations, and mixtures thereof.
A biocompatible article which is produced by contacting aqueous medium, water or body fluid and a flowable composition of a biocompatible, biodegradable, branched, thermoplastic polymer that is at least substantially insoluble in aqueous medium, water or body fluid, and a biocompatible organic solvent that is at least slightly soluble in aqueous medium, water or body fluid;
- wherein the polymer is selected from the group consisting of polyamides, polyurethanes, polyureas, copolymers, terpolymers, combinations, and mixtures thereof.
Dependencies are inferred from the claim text.