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US 6,527,957 B1Granted
Methods for separating, collecting and storing red blood cells
AssigneeBaxter International Inc.
InventorsJose C. Deniega, Daniel H. Duff, Maria D. Gudino, Donald H. Buchholz
Life of this patent
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Abstract
Methods are disclosed for the collection of red blood cells whereby whole blood is combined with an anticoagulant, red cells are separated from the whole blood and the separated red cells are combined with a storage solution. The red cells may be stored for an extended period of time.
Claims9
A method for providing viable red blood cells comprising:
- a) providing a quantity of whole blood;
- b) combining said whole blood with a selected quantity of a phosphate-free anticoagulant, wherein one liter of said anitcoagulant comprises approximately 7.3 g of citric acid, 22.0 g of trisodium citrate and 24.5 g of dextrose;
- c) separating said anticoagulated whole blood into components to provide concentrated red blood cells;
- d) combining said concentrated red blood cells with a solution, wherein one liter of said solution comprises approximately 22.0 g dextrose, 0.27 g adenine, 7.5 g mannitol and 9.0 g sodium chloride.
1 more element
A method for providing viable red blood cells comprising:
- a) providing a quantity of whole blood;
- b) combining said whole blood with a selected quantity of a phosphate-free anticoagulant, wherein one liter of said anticoagulant comprises approximately 7.3 g of citric acid, 22.0 g of trisodium citrate and 24.5 g of dextrose;
- c) separating said anticoagulated whole blood into components to provide concentrated red blood cells;
- d) combining said red blood cells with a solution, wherein one liter of said solution comprises approximately 22.0 g dextrose, 0.27 g adenine, 7.5 g mannitol and 9.0 g sodium chloride, whereby said red blood cells, if stored for a period of 42 days, maintain a red blood cell ATP level that is not less than approximately 80% of the initial ATP level at the beginning of the storage period.
1 more element
Dependencies are inferred from the claim text.