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US 6,525,046 B1Granted
Aromatic heterocyclic compounds as antiinflammatory agents
AssigneeBoehringer Ingelheim Pharmaceuticals, Inc.
InventorsPier Francesco Cirillo, Roger Dinallo, John Robinson Regan, Paul S. Riska, Alan David Swinamer, Zhulin Tan, Brian Andrew Walter
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Abstract
Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
Claims6
A compound selected from:
- 1-[5-(2-hydroxy-1,1-dimethyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-[4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 1-[5-tert-butyl-2-(3-hydroxy-4-methyl-phenyl)-2H-pyrazol-3-yl]-3-[4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 1-[5-tert-butyl-2-(4-hydroxymethyl-phenyl)-2H-pyrazol-3-yl]-3-[4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-{4-[2-(3-oxo-morpholin-4- yl)-ethoxy]-naphthalen-1-yl}-urea;
- 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-{4-[2-(4-oxy-morpholin-4- yl)-ethoxy]-naphthalen-1-yl}-urea;
- 1-[5-(2-hydroxy-1,1-dimethyl-ethyl)-2-(6-methyl-pyridin-3-yl)-2H- pyrazol-3-yl]-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 1-[5-tert-butyl)-2-(1-oxy-6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-3-[4- (2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 1-[5-tert-butyl)-2-(6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-3-{4-[2-(4- oxy-morpholin-4-yl)-ethoxy]-naphthalen-1-yl}-urea;
- 1-[5-(2-hydroxy-1,1-dimethyl-ethyl)-2-(6-methyl-pyridin-3-yl)-2H- pyrazol-3-yl]-3-[4-(2-pyridin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 1-[5-tert-butyl)-2-(6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-3-[4-(2- hydroxy-2-pyridin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 1-[5-tert-butyl)-2-(6-methyl-pyridin-3-yl)-2H-pyrazol-3-yl]-3-{4-[2-(1- oxy-pyridin-4-yl)-ethoxy]-naphthalen-1-yl}-urea;
- 1-[5-(2-hydroxy-1,1-dimethyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-{4-[2- (1-oxo-thiomorpholin-4-yl)-ethoxy]-naphthalen-1-yl}-urea;
- 1-[5-tert-butyl-2-(4-hydroxymethyl-phenyl)-2H-pyrazol-3-yl]-3-{4-[2-(1- oxo-thiomorpholin-4-yl)-ethoxy]-naphthalen-1-yl}-urea;
- 1-[5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl]-3-{4-[2-(1,3 dioxo- thiomorpholin-4-yl)-ethoxy]-naphthalen-1-yl}-urea;
- 1-[5-(2-hydroxy-1,1-dimethyl-ethyl)-2-methyl-2H-pyrazol-3-yl]-3-[4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea and 1-[5-tert-butyl-2-methyl-2H-pyrazol-3-yl]-3-{4-[2-(4-oxy-morpholin-4- yl)-ethoxy]-naphthalen-1-yl}-urea
- or physiologically acceptable acids or salts thereof.
13 more elements
A compound selected from:
- 1-[5-tert-Butyl-2-(2-hydroxy-4-methyl-phenyl)-2H-pyrazol-3-yl]-3-[4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 4-(3-tert-Butyl-5-{3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- ureido}-pyrazol-1-yl)-benzoic acid;
- 1-[5-(1,1-Dimethyl-2-oxo-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-[4-(2- morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea;
- 2-Methyl-2-(5-{3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]- ureido}-1-p-tolyl-1H-pyrazol-3-yl)-propionic acid;
- 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-2-oxo- ethoxy)-naphthalen-1-yl]-urea and 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{4-[2-(1-oxo-1λ4- thiomorpholin-4-yl)-ethoxy]-naphthalen-1-yl}-urea
- or physiologically acceptable acids or salts thereof.
3 more elements
Dependencies are inferred from the claim text.