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US 6,525,040 B1Granted
Cyclic organoselenium compounds, their preparation and their uses
AssigneeOxis Isle of Man, Limited
InventorsIrene Erdelmeier, Catherine Tailhan-Lomont, Marc Moutet, Jean Chaudiere, Jean-Claude Yadan
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Abstract
The invention is directed to novel cyclic organoselenium compounds useful as antioxidants, pharmaceutical compositions containing them, and methods for their preparation.
Claims28
A cyclic organoselenium compound of the general formula (I):
- in which:
- R1=hydrogen;
- lower alkyl;
- optionally substituted aryl;
- optionally substituted lower aralkyl;
- R2=hydrogen;
- lower alkyl;
- optionally substituted aryl;
- optionally substituted lower aralkyl;
- A=CO;
- (CR3R4)m;
- B=NR5;
- Ar=an optionally substituted radical of formula:
- in which:
- Z=O;
- S ;
- NR5;
- R3=hydrogen;
- lower alkyl;
- optionally substituted aryl;
- optionally substituted lower aralkyl;
- R4=hydrogen;
- lower alkyl;
- optionally substituted aryl;
- optionally substituted lower aralkyl;
- R5=hydrogen;
- lower alkyl;
- optionally substituted aryl;
- optionally substituted lower aralkyl;
- optionally substituted heteroaryl;
- optionally substituted lower heteroaralkyl;
- CO(lower alkyl);
- CO(aryl);
- SO2(lower alkyl);
- SO2(aryl);
- m=0 or 1;
- n=0 or 1;
- or a pharmaceutically acceptable salt of acids and bases.
35 more elements
Dependencies are inferred from the claim text.