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US 6,524,586 B2Granted
Enhancement of oligomeric viral immunogenicity
AssigneeAlbany Medical College
InventorMark D. Scott
Life of this patent
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Abstract
A method and structure for forming a viral-physiological structure. A naked virus having a capsid is provided. A linker molecule having a covalently attached polymer is covalently bonded to the capsid to form a polymer-protected virus. An immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.
Claims34
A method for enhancing an animal's immune response against a virus associated with a viral disease of said animal, comprising:
- protecting a naked virus with a polymer covalently attached to a linker molecule covalently bonded to the capsid of the naked virus, wherein the polymer is polyethylene glycol, methoxypolyethylene glycol, or ethoxypolyethylene glycol, and wherein said polymer-protected virus is more immunogenic with respect to the animal than is the unprotected naked virus;
- and
- introducing the polymer-protected virus into the animal in an amount sufficient to induce an immune response against the virus.
A method, comprising:
- covalently bonding a linker molecule to a carbohydrate at the capsid of a naked virus, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, and wherein an immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.
A structure, comprising:
- a linker molecule covalently bonded to the capsid of a naked virus, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, wherein the immunogenicity of the polymer-protected virus with respect to an animal exceeds the immunogenicity of the naked virus with respect to to the animal, wherein the naked virus has human significance, and wherein the polymer is selected from the group consisting of polyethylene glycol, methoxypolyethylene glycol, and ethoxypolyethylene glycol.
A structure, comprising:
- a linker molecule covalently bonded to a carbohydrate at the capsid of a naked virus, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, wherein an immunogenicity of the polymer-protected virus with respect to an animal exceeds an immunogenicity of the naked virus with respect to the animal.
A structure, comprising:
- a linker molecule covalently bonded to the capsid of a naked virus, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, wherein the polymer has a long chain length that causes the immunogenicity of the polymer-protected virus with respect to a given animal to exceed the immunogenicity of the virus with respect to the given animal, wherein the naked virus has human significance, and wherein the polymer is selected from the group consisting of polyethylene glycol, methoxypolyethylene glycol, and ethoxypolyethylene glycol.
A structure comprising:
- a linker molecule covalently bonded to the capsid of a naked virus, wherein a polymer is covalently attached to the linker molecule to form a polymer-protected virus, wherein a camouflaging of a charge site at the capsid by the polymer causes the immunogenicity of the polymer-protected virus with respect to a given animal to exceed the immunogenicity of the virus with respect to the given animal, wherein the naked virus has human significance.
Dependencies are inferred from the claim text.