Pyridine compounds and their pharmaceutical use
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsMasaki Tomishima, Kazuhiko Take
Life of this patent
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Abstract
A compound of formula (I) wherein each symbol is as defined in the specification, and pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NOS(nitric oxide synthasey)-mediated diseases such as adult respiratory distress syndrome, myocarditis, synovitis, septic shock, insulin-ependent diabetes mellitus, ulcerative colitis, cerebral infarction, rheumatoid arthritis, osteoarthritis, osteoporosis, systemic lupus erythematosus, rejection by organ transplantation, asthma, pain, ulcer, and the like in human being and animals.
Claims11
A compound of the formula
- wherein
- R1 and R2 are the same or different and each is hydrogen, lower alkyl, lower alkoxy, cyano, lower alkoxycarbonyl, carboxy, lower haloalkyl, hydroxy(lower)alkyl, hydroxy, nitro, amino, mono or di(lower)alkylamino, protected hydroxy or lower alkyl substituted by protected hydroxy;
- X is a single bond or a group of the formula selected from the group consisting of
- wherein R4 is hydrogen or acyl;
- ring A is heterocycle or arylene wherein said heterocycle and arylene may be substituted by suitable substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen and guanidino which may be substituted by suitable substituent(s);
- and
- R3 is a group of the formula selected from the group consisting of
- wherein R5 is hydrogen, lower alkyl, lower alkylthio, amino which may be substituted by suitable substituent(s) or aromatic heterocyclic group, or
- when
- may form a bicyclic group selected from the group consisting of
- wherein said bicyclic group may be substituted by suitable substituent(s) selected from the group consisting of lower alkyl and aryl,
- R6 and R7 are the same or different and each is hydrogen, lower alkyl, cyano, amino, hydroxy, acyl or amidino which may be substituted by suitable substituent(s), and
- R8 is thiazolinyl or pyridyl,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.