Method of carrying out blood tests
AssigneeRhein Biotech Gesellschaft fur Neue Biotechnologische Prozesse und Produkte mbH
InventorsAlexander W. M. Strasser, Karl Melber, Hans Dietrich Menssen, Eckard Thiel
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Abstract
The present invention relates to a method of carrying out blood tests. The invention is based on the finding that clinico-chemical blood parameters can be determined using not only blood serum but also blood plasma. Therefore, freshly taken blood samples, which are mixed with at least one thrombin inhibitor, can be used for determining both clinico-chemical parameters and hematological parameters. The clinico-chemical parameters can thus be determined using blood plasma, a separation of coagulable components being not required any more.
Claims21
A method of determining clinico-chemical and hematological parameters on blood, comprising the steps of mixing a freshly taken blood sample with at least one direct, specific thrombin inhibitor and using said blood sample for determining both clinico-chemical parameters and hematological parameters,
- wherein the clinico-chemical parameters are selected from the group consisting of glutamine-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), alkaline phosphatase, amylase, lipase, γ-glutamyl transferase (GGT), lactate dehydrogenase (LDH), creatine kinase, liver enzymes, cholinesterase, α-hydroxybutyrate dehydrogenase (α-HBDH);
- creatinine, urea, uric acid, bilirubin, glucose, total cholesterol, triglycerides;
- sodium, potassium, chloride, magnesium, phosphate, calcium;
- coagulation parameters C3, C4 and quick prothrombin time;
- β-human chorionic gonadotropin (β-HCG), T3, T4, and TSH basal hormones;
- iron, transferrin, hemoglobin, total protein, protein electrophoresis, albumin, C-reactive protein, immunoglobulins, antistreptolysin titer, rheumatoid factors, apolipoprotein, digitoxin, vancomycin, theophylline, and osmolality, and
- the hematological parameters are selected from the group consisting of erythrocyte, leukocyte and thrombocyte counts, leukocyte fraction of nucleated blood cells (differential count), antigenicity of blood cells, immunophenotyping of mononuclear cells, antibody screening tests, Coombs test, and blood sedimentation rate.
A method for determining clinico-chemical blood parameters, comprising the steps of mixing a freshly taken blood sample with an anticoagulant consisting essentially of at least one specific, direct thrombin inhibitor and determining the clinico-chemical parameters using the resulting blood sample,
- wherein said clinico-chemical blood parameters are selected from the group consisting of glutamine-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), alkaline phosphatase, amylase, lipase, γ-glutamyl transferase (GGT), lactate dehydrogenase (LDH), creatine kinase, liver enzymes, cholinesterase, α-hydroxybutyrate delydrogenase (α-HBDH);
- creatinine, urea, uric acid, bilirubin, glucose, total cholesterol, triglycerides;
- sodium, potassium, chloride, magnesium, phosphate, calcium;
- coagulation parameters C3, C4 and quick prothrombin time;
- β-human chorionic gonadotropin (β-HCG), T3, T4, and TSH basal hormones;
- iron, transferrin, hemoglobin, total protein, protein electrophoresis, albumin, C-reactive protein, immunoglobulins, antistreptolysin titer, rheumatoid factors, apolipoprotein, digitoxin, vancomycin, theophylline, and osmolality.
A method of using blood withdrawal containers containing at least one direct, specific thrombin inhibitor, comprising collecting blood in said containers and determining both clinico-chemical and hematological parameters,
- wherein the clinico-chemical parameters are selected from the group consisting of glutamine-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), alkaline phosphatase, amylase, lipase, γ-glutamyl transferase (GGT), lactate dehydrogenase (LDH), creatine kinase, liver enzymes, cholinesterase, α-hydroxybutyrate dehydrogenase (α-HBDH);
- creatinine, urea, uric acid, bilirubin, glucose, total cholesterol, triglycerides;
- sodium, potassium, chloride, magnesium, phosphate, calcium;
- coagulation parameters C3, C4 and quick prothrombin time;
- β-human chorionic gonadotropin (β-HCG), T3, T4, and TSH basal hormones;
- iron, transferrin, hemoglobin, total protein, protein electrophoresis, albumin, C-reactive protein, immunoglobulins, antistreptolysin titer, rheumatoid factors, apolipoprotein, digitoxin, vancomycin, theophylline, and osmolality, and
- the hematological parameters are selected from the group consisting of erythrocyte, leukocyte and thrombocyte counts, leukocyte fraction of nucleated blood cells (differential count), antigenicity of blood cells, immunophenotyping of mononuclear cells, antibody screening tests, Coombs test, and blood sedimentation rate.
A method of using blood withdrawal containers containing an anticoagulant consisting essentially of at least one direct, specific thrombin inhibitor, comprising collecting blood in said containers and determining clinico-chemical parameters,
- wherein the clinico-chemical parameters are selected from the group consisting of glutamine-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), alkaline phosphatase, amylase, lipase, γ-glutamyl transferase (GGT), lactate dehydrogenase (LDH), creatine kinase, liver enzymes, cholinesterase, α-hydroxybutyrate dehydrogenase (α-HBDH);
- creatinine, urea, uric acid, bilirubin, glucose, total cholesterol, triglycerides;
- sodium, potassium, chloride, magnesium phosphate, calcium;
- coagulation parameters C3, C4 and quick prothrombin time;
- β-human chorionic gonadotropin (β-HCG), T3, T4, and TSH basal hormones;
- iron, transferrin, hemoglobin, total protein, protein electrophoresis, albumin, C-reactive protein, immunoglobulins, antistreptolysin titer, rheumatoid factors, apolipoprotein, digitoxin, vancomycin, theophyllin, and osmolality.
Dependencies are inferred from the claim text.