Loading patent…
AssigneeAccess Pharmaceuticals, Inc.
InventorsPatrick F. Kiser, Allen A. Thomas
Estimating the term…
Biodegradable cross-linkers are provided having a polyacid core with at least two acidic groups covalently connected to reactive groups usable to cross-link polymer filaments. Between at least one reactive group and an acidic group of the polyacid is a biodegradable region which preferably consists of a hydroxyalkyl acid ester sequence having 1, 2, 3, 4, 5 or 6 hydroxyalkyl acid ester groups. The polyacid may be attached to a water soluble region that is attached to the biodegradable region having attached reactive groups. The hydroxyalkyl acid ester group is preferably a lactate or glycolate. Polyacids include diacids, triacids, tetraacids and pentaacids, and the reactive group may contain a carbon-carbon double bond. A network of cross-linked polymer filaments having adefined biodegradation rate can be formed using the cross-linkers. The network may contain biologically active molecules, and can be in the form of a microparticle or nanoparticle, or hydrogel. The polymer filaments may be preformed polymer filaments of polynucleic acids, polypeptides, proteins or carbohydrates. The cross-linkers may be copolymerized with charged monomers such as acrylic monomers containing charged groups. Applications of the cross-linkers and network include controlled release of drugs and cosmetics, tissue engineering, wound healing, hazardous waste remediation, metal chelation, swellable devices for absorbing liquids and prevention of surgical adhesions.
A monomeric or oligomeric cross-linker comprising a polyacid with at least two acidic groups directly or indirectly being covalently connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and an acidic group of the polyacid is a biodegradable sequence consisting of a hydroxyalkyl acid ester sequence having a number of hydroxyalkyl acid ester groups selected from the group consisting of 1, 2, 3, 4, 5 and 6;
The cross-linker of claim 1, or network of claim 25 wherein the polyacid has a molecular weight between 60 and 400 Da;
A network of cross-linked polymer filaments with a defined biodegradation rate and cross-linked by a monomeric or oligomeric cross-linker comprising a polyacid with at least two acidic groups directly or indirectly covalently connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and an acidic group of the polyacid is a biodegradable sequence consisting of a hydroxyalkyl acid ester sequence having a number of hydroxyalkyl acid ester groups selected from the group consisting of 1, 2, 3, 4, 5 and 6.
A network of cross-linked polymer filaments with a defined biodegradation rate under in vivo mammalian conditions formed of preformed polymer filaments of polynucleic acids, polypeptides, proteins or carbohydrates and cross-linked by a monomeric or oligomeric cross-linker comprising a polyacid with at least two acidic groups directly or indirectly covalently connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and an acidic group of the polyacid is a biodegradable sequence consisting of a hydroxyalkyl acid ester sequence having a number of hydroxyalkyl acid ester groups selected from the group consisting of 1, 2, 3, 4, 5 and 6.
A network of cross-linked polymer filaments with a defined biodegradation rate under mammalian in vivo conditions, cross-linked by a monomeric or oligomeric cross-linker comprising a polyacid with at least two acidic groups directly or indirectly covalently connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and an acidic group of the polyacid is a biodegradable sequence consisting of a hydroxyalkyl acid ester sequence having a number of hydroxyalkyl acid ester groups selected from the group consisting of 1, 2, 3, 4, 5 and 6;
A network of cross-linked polymer filaments with a defined biodegradation rate under mammalian in vivo conditions cross-linked by a monomeric or oligomeric cross-linker comprising a polyacid with at least two acidic groups directly or indirectly covalently connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and an acidic group of the polyacid is a biodegradable sequence consisting of a hydroxyalkyl acid ester sequence having a number of hydroxyalkyl acid ester groups selected from the group consisting of 1, 2, 3, 4, 5 and 6, and the network comprising an organic radioisotope, inorganic radioisotope or nuclear magnetic resonance relaxation reagent.
A microparticle or nanoparticle cross-linked polymer composition with a defined biodegradation rate under mammalian in vivo conditions and containing polymer filaments cross-linked by a monomeric or oligomeric cross-linker comprising a polyacid with at least two acidic groups directly or indirectly covalently connected to reactive groups usable to cross-link polymer filaments wherein between at least one reactive group and an acidic group of the polyacid is a biodegradable sequence consisting of a hydroxyalkyl acid ester sequence having a number of
Dependencies are inferred from the claim text.