US 6,521,211 B1Granted

Methods of imaging and treatment with targeted compositions

AssigneeBristol-Myers Squibb Medical Imaging, Inc.

InventorsEvan C. Unger, Yunqiu Wu

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Abstract

Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The scanning may comprise exposing the patient to a first type of ultrasound energy and then interrogating the patient using a second type of ultrasound energy. The targeting ligand preferably targets tissues, cells or receptors, including myocardial cells, endothelial cells, epithelial cells, tumor cells and the glycoprotein GPIIbIIIa receptor. The methods may be used to detect a thrombus, enhancement of an old or echogenic thrombus, low concentrations of vesicles and vesicles targeted to tissues, cells or receptors.

Claims58

Dependent claims

A diagnostic ultrasound method comprising (i) administering to a patient a targeted vesicle composition which comprises vesicles encapsulating a gas, in combination with a targeting ligand;

and (ii) scanning the patient using dual frequency ultrasound insonation, wherein said vesicles are selected from the group consisting of liposomes and micelles, and said vesicles comprise a phospholipid selected from the group consisting of dioleoylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, distearoylphosphatidylcholine, dipalmitoylphosphatidylethanolamine, dioleoylphosphatidylethanolamine, N-succinyldioleoylphosphatidylethanolamine,1 -hexadecyl-2-palmitoylglycerophosphoethanolamine, and phosphatidic acids, and wherein said scanning comprises exposing the patient to a first ultrasound energy having a first insonation frequency to cause the vesicle to oscillate, and then subsequently, while the vesicle is oscillating, exposing the patient to a second ultrasound energy having a second insonation frequency that is different from said first insonation frequency, and detecting the reflected ultrasound signal.

Dependencies are inferred from the claim text.

Facts

Application: 09/243,640Filed 3 Feb 1999 · continuation in part
Priority: 7 Jun 1995
Granted: 18 Feb 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

A61K 49/225
Characterised by a special physical form, e.g. emulsions, liposomes: microparticles, microcapsules
A61K 49/223
Characterised by a special physical form, e.g. emulsions, liposomes: microbubbles, hollow microspheres, free gas bubbles, gas microspheres
A61K 49/227
Characterised by a special physical form, e.g. emulsions, liposomes: liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g.…
A61K 49/228
Characterised by a special physical form, e.g. emulsions, liposomes: host-guest complexes, clathrates, chelates

Family

Application08/497,684Parent of this continuation-in-part · filed 7 Jun 1995
Application08/640,464Parent of this continuation-in-part · filed 1 May 1996
Application08/660,032Parent of this continuation-in-part · filed 6 Jun 1996
Application60/073,913Us provisional application · filed 6 Feb 1998
Application09/218,660Parent of this continuation-in-part · filed 22 Dec 1998
US 6,521,211 B1This patent

From the US filing history. Foreign family members aren’t listed.