Process for selective oxidation of primary alcohols
AssigneeNederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
InventorsJan Pieter Van Der Lugt, Jan Matthijs Jetten, Arie Cornelis Besemer, Hendrik Arend Van Doren
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Abstract
Primary alcohols, especially in carbohydrates, can be selectively oxidized to aldehydes and carboxylic acids in a low-halogen process by using a peracid in the presence of a catalytic amount of a di-tertiary-alkyl nitroxyl (TEMPO) and a catalytic amount of halide. The halide is preferably bromide and the process can be carried out at nearly neutral to moderately alkaline pH (5-11). The peracid can be produced or regenerated by means of hydrogen peroxide or oxygen. The process is advantageous for producing uronic acids and for introducing aldehyde groups which are suitable for crosslinking and derivatization.
Claims12
A process for oxidizing a primary alcohol using an oxidizing agent in the presence of a catalytic amount of a di-tertiary-alkyl nitroxyl, comprising subjecting the primary alcohol to a peracid or a precursor thereof as the oxidizing agent and to said di-tertiary nitroxyl, in the presence of 0.1-40 mol % of halide, with respect to the primary alcohol.
Dependencies are inferred from the claim text.