Dry powder compositions having improved dispersivity
AssigneeInhale Therapeutic Systems
InventorsMei-Chang Kuo, David Lechuga-Ballesteros
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Abstract
The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention possesses superior aerosol properties and is thus preferred for aerosolized administration to the lung. Also provided are a method for (i) increasing the dispersibility of an active-agent containing formulation for administration to the lung, and (ii) delivery of the composition to the lungs of a subject.
Claims40
A dry powder composition comprising an active agent and a di- or tripeptide comprising at least two leucines.
A method for enhancing the aerosol performance of a dry powder, said method comprising:
- incorporating into a liquid formulation comprising an active agent, a di- or tri-peptide comprising at least two leucines, and
- drying said liquid formulation such that a dry powder containing the active agent and the di- or tri-peptide is produced,
- whereby the resultant dry powder possesses an emitted dose that is increased over the emitted dose of a dry powder having the same components but absent said di- or tri-peptide.
A method for increasing the aerosol performance of an active agent-containing formulation suitable for administration to the lung, said method comprising:
- incorporating a di- or tripeptide comprising at least two leucines into a formulation comprising an active agent, to thereby form a composition comprising said active agent and said di- or tripeptide,
- whereby as a result of said incorporating, the emitted dose of the composition is increased over the emitted dose of a composition having the same components but absent said di- or tripeptide.
Dependencies are inferred from the claim text.