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US 6,517,869 B1Granted
Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
AssigneeExpression Genetics, Inc.
InventorsJong-Sang Park, Min-Hyo Seo
Life of this patent
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Abstract
A biodegradable, positively-charged aminoalkyl polyester polymer for the delivery of bioactive agents, such as DNA, RNA, oligonucleotides is disclosed. Biologically active moieties, such as drugs, ligands, and the like, can be coupled to the free amino groups of the polymer.
Claims21
A biodegradable polyester polymer represented by the formula
- wherein n is an integer from 10 to 250;
- p is an integer from 2 to 9;
- and R1 and R2 are selected from the group consisting of H, alkyl of 1 to 20 carbon atoms, alkaryl of 7 to 20 carbon atoms, carbohydrates, polyethylene glycol and peptides.
A biodegradable, amphiphilic polyester block copolymer comprising:
- (a) a first polymer represented by the formula
- wherein n is an integer 10 to 250;
- p is an integer from 2 to 9;
- and R1 and R2 are selected from the group consisting of H, alkyls of 1 to 20 carbon atoms, alkaryl of 7 to 20 carbon atoms, carbohydrates, polyethylene glycol and peptides;
- and
- (b) a second polymer bonded to the first polymer, wherein the second polymer is a member selected from the group consisting of poly(D-lactic acid), poly(L-lactic acid), poly(DL-lactic acid), poly(D-lactide), poly(L-lactide), poly(DL-lactide), polyglycolic acid, polyglycolides, poly(lactic-co-glycolic acids), poly[α-(4-aminobutyl) lactic acid] and polycaprolactone;
- wherein the weight ratio of the first and the second polymer is within a range of 20:80 and 80:20.
4 more elements
A biodegradable polyester random copolymer comprising:
- (a) a first monomer represented by the formula
- wherein p is an integer from 2 to 9;
- and R1 and R2 are selected from the group consisting of H, alkyls of 1 to 20 carbon atoms, alkaryl of 7 to 20 carbon atoms, carbohydrates, polyethylene glycol and peptides;
- and
- (b) a second monomer selected from the group consisting of D-lactic acid, L-lactic acid, D-lactide, L-lactide, glycolic acid, glycolide, α-(4-aminobutyl) lactic acid and caprolactone, wherein the weight ratio of the first and the second monomer is within a range of 20:80 and 80:20.
2 more elements
Dependencies are inferred from the claim text.