Marburg virus vaccines
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsMichael C. Hevey, Diane L. Negley, Peter Pushko, Jonathan F. Smith, Alan L. Schmaljohn
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Abstract
The invention here relates to recombinant DNA constructs which comprise a Venezuelan equine encephalitis replicon vector and at least one DNA fragment encoding a protective antigen from the Marburg virus. The DNA constructs are useful for inducing an immune response which is protective against infection with Marburg virus in nonhuman primates.
Claims12
A recombinant DNA construct comprising:
- (i) a Venezuelan equine encephalitis replicon vector, and
- (ii) at least one DNA fragment encoding a protective antigen from the Musoke strain of the Marburg virus.
A pharmaceutical composition comprising one or more recombinant DNA constructs chosen from the group consisting of pRep Mus GP, pRep Mus GPΔTM, pRep Mus NP, pRep Mus VP40, pRep Mus VP35, pRep Mus VP30, pRep Mus VP24 in a pharmaceutically acceptable amount, in a pharmaceutically accpetable carrier/and or adjuvant.
Dependencies are inferred from the claim text.