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AssigneeUnilever Patent Holdings B.V.
InventorsLeon Gerardus Joseph Frenken, Michael Marie Harmsen, Richard Hendricus Jacobus van der Linden, Cornelis Theodorus Verrips
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New products are provided comprising inactivated lower eukaryotic cells, preferably yeasts or molds, having at the outer surface functionally active antibodies or functionally active fragments thereof. Preferred antibody fragments are the variable domains of Camelidae heavy chain antibodies, which are surprisingly stable against physical and chemical decontamination regimes and do not loose their activity when they are immobilized on the glucan layer of the cell wall which is present in a variety of lower eukaryotes. The new products are preferably in the field of food products, personal care products, and animal feed products.
A product comprising inactivated lower eukaryotic cells having expressed and immobilised at their outer surface one or more functionally active heavy chain antibodies from an animal belonging to the family Camelidae or one or more functionally active fragments thereof, wherein said one or more antibodies or functionally active fragments thereof retain their functionality by over 60% after the lower eukaryotic cells are inactivated.
Animal feed products containing inactivated yeast cells having expressed and immobilised on their surface one or more functional heavy chain antibodies specific to microorganisms pathogenic to animals or functionally active fragments thereof from an animal belonging to the family Camelidae, wherein said one or more antibodies or functionally active fragments thereof retain their functionality by over 60% after the lower eukaryotic cells are inactivated.
A product comprising inactivated lower eukaryotic cells, which have expressed therein one or more heavy chain antibodies specific for a pathogenic microorganism or functionally active fragments thereof obtained from an animal belonging to the family Camelidae such that said one or more heavy chain antibodies or functionally active fragments are immobilised at the outer surface of said lower eukaryotic cells, and wherein said lower eukaryotes have been inactivated by killing them with an efficiency of greater than 106;
A product to which has been added lower eukaryotic cells, which have expressed therein one or more heavy chain antibodies specific for a pathogenic microorganism or functionally active fragments thereof obtained from an animal belonging to the family Camelidae such that said one or more heavy chain antibodies or functionally active fragments are immobilised at the outer surface of said lower eukaryotic cells, and said lower eukaryotic cells have been inactivated by killing them with an efficiency of greater than 106;
Dependencies are inferred from the claim text.