Frangible compounds for pathogen inactivation

A compound having the formula:

• where R1, R2, R3, R4, R5, R6, R7, and R8 are independently selected from the group consisting of —H, —R10, —O—R10, —NO2, —NH2, —NH—R10, —N(R10)2, —F, —Cl, —Br, —I, —C(═O)—R10, —C(═O)—O—R10, and —O—C(═O)—R10,
• where —R10 is independently H, —C1-8alkyl, —C1-8heteroalkyl, -aryl, -heteroaryl, —C1-3alkyl-aryl, —C1-3heteroalkyl-aryl, —C1-3alkyl-heteroaryl, —C1-3heteroalkyl-heteroaryl, -aryl-C1-3alkyl, -aryl-C1-3heteroalkyl, -heteroaryl-C1-3alkyl, -heteroaryl-C1-3heteroalkyl, —C1-3alkyl-aryl-C1-3alkyl, —C1-3heteroalkyl-aryl-C1-3alkyl, —C1-3alkyl-heteroaryl-C1-3alkyl, —C1-3alkyl-aryl-C1-3heteroalkyl, —C1-3heteroalkyl-heteroaryl-C1-3alkyl, —C1-3heteroalkyl-aryl-C1-3heteroalkyl, —C1-3alkyl-heteroaryl-C1-3heteroalkyl, or —C1-3heteroalkyl-heteroaryl-C1-3heteroalkyl;
• R20 is —H or —CH3;
• and
• R21, is —R11—W—X—E,
• where —R11— is independently —C1-8alkyl-, —C1-8heteroalkyl-, -aryl-, -heteroaryl-, —C1-3alkyl-aryl-, —C1-3heteroalkyl-aryl-, —C1-3alkyl-heteroaryl-, —C1-3heteroalkyl-heteroaryl-, -aryl-C1-3alkyl-, -aryl-C1-3heteroalkyl-, -heteroaryl-C1-3alkyl-, -heteroaryl-C1-3heteroalkyl-, —C1-3alkyl-aryl-C1-3alkyl-, —C1-3heteroalkyl-aryl-C1-3alkyl-, —C1-3alkyl-heteroaryl-C1-3alkyl-, —C1-3alkyl-aryl-C1-3heteroalkyl-, —C1-3heteroalkyl-heteroaryl-C1-3alkyl-, —C1-3heteroalkyl-aryl -C1-3heteroalkyl-, —C1-3alkyl-heteroaryl-C1-3heteroalkyl-, or —C1-3heteroalkyl-heteroaryl-C1-3heteroalkyl-;
• W is independently —C(═O)—O—, —O—C(═O)—, —C(═S)—O—, —O—C(═S)—, —C(═S)—S—, —C—C(═S)—, —C(═O)—S—, —S—C(═O)—, —O—S(═O)2—O—, —S(═O)2—O—, —O—S(═O)2—, —O—P(═O)(—OR10)—O—, —O—P(═O)(—OR10)—O—, —P(═O)(—OR10)—O—, —O—P(═O)(—OR10)—;
• X is independently —R11—;
• and
• E is independently selected from the group consisting of —N(R12)2, —N(R12)(R13), —S—R12, and
• where —R12 is —CH2CH2—G, where each G is independently —Cl, —Br, —I, —O—S(═O)2—CH3, —O—S(═O)2—CH2—C6H5, or —O—S(═O)2—C6H4—CH3;
• and where R13 is independently —C1-8alkyl, —C1-8heteroalkyl, -aryl, -heteroaryl, —C1-3alkyl-aryl, —C1-3heteroalkyl-aryl, —C1-3alkyl-heteroaryl, —C1-3heteroalkyl-heteroaryl, -aryl-C1-3alkyl, -aryl-C1-3heteroalkyl, -heteroaryl-C1-3alkyl, -heteroaryl-C1-3heteroalkyl, —C1-3alkyl-aryl-C1-3alkyl, —C1-3heteroalkyl-aryl-C3alkyl, —C1-3alkyl-heteroaryl-C1-3alkyl, —C1-3alkyl-aryl-C1-3heteroalkyl, —C1-3heteroalkyl-heteroaryl-C1-3alkyl, —C1-3heteroalkyl-aryl-C1-3heteroalkyl, —C1-3alkyl-heteroaryl-C1-3heteroalkyl, or —C1-3heteroalkyl-heteroaryl-C1-3heteroalkyl;
• and all salts and stereoisomers [(including enantiomers and diastereomers)] thereof.