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US 6,514,534 B1Granted
Methods for forming regional tissue adherent barriers and drug delivery systems
AssigneeIncept, LLC
InventorAmarpreet S. Sawhney
Life of this patent
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AssigneeIncept, LLC
InventorAmarpreet S. Sawhney
Estimating the term…
Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-nucleophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.
A method of forming a regional barrier to reduce adhesion of tissue to internal structures in a body cavity following surgery comprising:
A method of delivering bioactive molecules to internal structures in a body cavity following surgery comprising:
Dependencies are inferred from the claim text.