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US 6,514,514 B1Granted
Device and method for regeneration and repair of cartilage lesions
AssigneeSulzer Biologics, Inc.
InventorsBrent Atkinson, James J. Benedict
Life of this patent
Estimating the term…
Abstract
Disclosed is a cartilage repair product that induces both cell ingrowth into a bioresorbable material and cell differentiation into cartilage tissue. Such a product is useful for regenerating and/or repairing both vascular and avascular cartilage lesions, particularly articular cartilage lesions, and even more particularly mensical tissue lesions, including tears as well as segmental defects. Also disclosed is a method of regenerating and repairing cartilage lesions using such a product.
Claims58
A product for repair meniscal cartilage lesions, comprising:
- a. a cartilage repair matrix selected from the group consisting of:
- a matrix configured as a sheet which conforms to a meniscal radial tear, a matrix configured as a sheet which conforms to a meniscal longitudinal tear, a matrix configured as a tapered shape which conforms to a segmental defect in a meniscus, and a matrix configured as a meniscus or a segmental portion thereof;
- b. a cartilage-inducing composition contained on or within said matrix comprising a mixture of proteins comprising:
- i. transforming growth factor β (TGFβ) superfamily proteins:
- TGFβ1, TGFβ2, TGFβ3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, and cartilage-derived morphogenetic protein (CDMP);
- wherein said TGFβ superfamily proteins comprise from about 0.1% to about 50% of said mixture of proteins;
- ii. bone matrix proteins:
- osteocalcin, osteonectin, bone sialoprotein (BSP), lysyloxidase, and cathepsin L pre;
- wherein said bone matrix proteins comprise from about 20% to about 98% of said mixture of proteins;
- and,
- iii. fibroblast growth factor-I (FGF-I), wherein said FGF-I comprises from about 0.01% to about 50% of said mixture of proteins.
8 more elements
A method for repair of meniscal cartilage lesions, comprising implanting and fixing into a meniscal cartilage lesion a product comprising:
- a. a cartilage repair matrix;
- and
- b. a cartilage-inducing composition contained on or within said matrix comprising a mixture of proteins comprising:
- i. transforming growth factor β (TGFβ) superfamily proteins:
- TGFβ1, TGFβ2, TGFβ3, bone morphogenetic protein (BMP)-2, BMP-3, BMP4, BMP-5, BMP-6, BMP-7, and cartilage-derived morphogenetic protein (CDMP);
- wherein said TGFβ superfamily proteins comprise from about 0.1% to about 50% of said mixture of proteins;
- ii. bone matrix proteins:
- osteocalcin, osteonectin, bone sialoprotein (BSP), lysyloxidase, and cathepsin L pre;
- wherein said bone matrix proteins comprise from about 20% to about 98% of said mixture of proteins;
- and,
- iii. fibroblast growth factor-I (FGF-I), wherein said FGF-I comprises from about 0.01% to about 50% of said mixture of proteins.
8 more elements
A product for repair of vascular and avascular meniscus tears, comprising:
- a. a cartilage repair matrix comprising collagen selected from the group consisting of:
- a matrix configured as a sheet which conforms to a meniscal radial tear, a matrix configured as a sheet which conforms to a meniscal bucket handle tear, a matrix configured as a sheet which conforms to a meniscal longitudinal tear;
- and
- b. a cartilage-inducing composition contained on or within said matrix comprising a mixture of proteins comprising:
- i. transforming growth factor β (TGFβ) superfamily proteins:
- TGFβ1, TGFβ2, TGFβ3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, and cartilage-derived morphogenetic protein (CDMP);
- wherein said TGFβ superfamily proteins comprise from about 0.1% to about 50% of said mixture of proteins;
- ii. bone matrix proteins:
- osteocalcin, osteonectin, bone sialoprotein (BSP), lysyloxidase, and cathepsin L pre;
- wherein said bone matrix proteins comprise from about 20% to about 98% of said mixture of proteins;
- and,
- iii. fibroblast growth factor-I (FGF-I), wherein said FGF-I comprises from about 0.01% to about 50% of said mixture of proteins.
9 more elements
A method for repair of vascular meniscus lesions, comprising implanting and fixing into a cartilage lesion in the vascular region of a meniscus a product comprising:
- a. a cartilage repair matrix comprising collagen and configured as a sheet;
- and
- b. a cartilage-inducing composition contained on or within said matrix comprising a mixture of proteins comprising:
- i. transforming growth factor β (TGFβ) superfamily proteins:
- TGFβ1, TGFβ2, TGFβ3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, and cartilage-derived morphogenetic protein (CDMP);
- wherein said TGFβ superfamily proteins comprise from about 0.1% to about 50% of said mixture of proteins;
- ii. bone matrix proteins:
- osteocalcin, osteonectin, bone sialoprotein (BSP), lysyloxidase, and cathepsin L pre;
- wherein said bone matrix proteins comprise from about 20% to about 98% of said mixture of proteins;
- and,
- iii. fibroblast growth factor-I (FGF-I), wherein said FGF-I comprises from about 0.01% to about 50% of said mixture of proteins.
8 more elements
A product for repair of meniscal cartilage lesions, comprising:
- a. a cartilage repair matrix selected from the group consisting of:
- a matrix configured as a sheet which conforms to a meniscal radial tear, a matrix configured as a sheet which conforms to a meniscal bucket handle tear, a matrix configured as a sheet which conforms to a meniscal longitudinal tear, a matrix configured as a tapered shape which conforms to a segmental defect in a meniscus, and a matrix configured as a meniscus or a segmental portion thereof;
- and
- b. a cartilage-inducing composition associated with said matrix, said composition comprising at least BMP-3, BMP-2 and TGFβ1, wherein the quantity of BMP-3 in said composition is about 2-6 fold greater than the quantity of BMP-2 and about 10-30 fold greater than the quantity of TGFP1 in said composition.
1 more element
Dependencies are inferred from the claim text.