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US 6,514,491 B1Granted
Hydrolytically degradable carbamate derivatives of poly(ethylene glycol)
AssigneeShearwater Corporation
InventorsMichael David Bentley, Xuan Zhao
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Abstract
Poly(ethylene glycol) carbamate derivatives useful as water-soluble pro-drugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydrogels. In such degradable hydrogels, drugs may be either trapped in the gel and released by diffusion as the gel degrades, or they may be covalently bound through hydrolyzable carbamate linkages. Hydrolysis of these carbamate linkages releases the amine drug at a controllable rate as the gel degrades.
Claims32
A compound having the formula:
- wherein:
- POLY is a water soluble and non-peptidic polymer;
- L is a hydrolytically stable linkage;
- Ar is an aromatic group;
- and
- Y is a biologically active agent.
3 more elements
A compound having the formula:
- wherein:
- L is —O— or —NHCO—;
- Y is a biologically active agent;
- POLY is poly(ethylene glycol) having a capping group selected from the group consisting of —OH, C1-4 alkoxy, and
- wherein Y and L are as described.
2 more elements
Dependencies are inferred from the claim text.