Acylaminoalkyl-substituted benzenesulfonamide derivatives, their preparation, their use and pharmaceutical preparations comprising them

A compound of the formula (I),

• wherein
• R(1) is
• a) (C1-C4)-alkyl;
• or
• b) —O—(C1-C4)-alkyl, which is unsubstituted or is substituted by 1, 2, or 3 fluorine atoms;
• or
• c) —O—(C1-C4)-alkyl which is substituted by a substituent chosen from nitro, ((C1-C4)-alkyl)carbonylamino, (C1-C4)-alkylamino, di((C1-C4)-alkyl)amino, hydroxycarbonyl, ((C1-C4)-alkoxy)carbonyl, piperidin-1-yl, morpholin-4-yl, tetrahydrofuranyl, tetrahydropyranyl, phenyl and phenoxy;
• wherein the phenyl group and the phenoxy group are unsubstituted or are substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl;
• or
• d) —O—(C1-C4)-alkyl-E(1)-(C1-C4)-alkyl-D(1), in which D(1) is hydrogen or —E(2)-(C1-C4)-alkyl-D(2), in which D(2) is hydrogen or —E(3)-(C1-C4)-alkyl, wherein E(1), E(2) and E(3), which are independent of one another and can be identical or different, are chosen from O, S, and NH;
• or
• e) —O—(C1-C4)-alkyl-O—(C1-C4)-alkyl, which is substituted in the terminal alkoxy group by 1, 2, or 3 fluorine atoms;
• or
• f) —O—(C2-C4)-alkenyl;
• or
• g) —O-phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, and trifluoromethyl;
• or
• h) halogen;
• or
• i) phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy, —S(O)m—(C1-C4)-alkyl, phenyl, amino, hydroxyl, nitro, trifluoromethyl, cyano, hydroxycarbonyl, carbamoyl, ((C1-C4)-alkoxy)carbonyl, and formyl;
• or
• j) (C2-C5)-alkenyl, which is unsubstituted or is substituted by a substituent chosen from phenyl, cyano, hydroxycarbonyl, and ((C1-C4)-alkoxy)carbonyl;
• or
• k) (C2-C5)-alkynyl, which is unsubstituted or is substituted by a substituent chosen from phenyl and (C1-C4)-alkoxy;
• or
• l) 5-membered or 6-membered monocyclic heteroaryl having one or two identical or different ring heteroatoms chosen from oxygen, sulfur, and nitrogen;
• or
• m) —S(O)m-phenyl, which is unsubstituted or is substituted by one or two identical or different substituents chosen from halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy and trifluoromethyl;
• R(2) is hydrogen, (C1-C6)-alkyl, or (C3-C7)-cycloalkyl, but is not hydrogen if Z is oxygen;
• the residues R(3), which are all independent of one another and can be identical or different, are hydrogen or (C1-C3)-alkyl;
• A is chosen from:
• wherein the free bond via which the residue A is bonded to the amino group in the formula (I) is represented by the symbol ;
• X is oxygen or sulfur;
• Y is —(CR(3)2)n—;
• Z is NH or oxygen;
• m is 0, 1 or 2;
• n is 1, 2, 3 or 4;
• or a stereoisomeric form of a compound of formula (I), or a mixture of at least two stereoisomeric forms of a compound of formula (I), or a physiologically tolerable salt of a compound of formula (I).