Substituted perhalogenated phthalocyanines
AssigneeBrown University Research Foundation
InventorSergiu M. Gorun
Life of this patent
Estimating the term…
Abstract
Phthalocyanine compounds of the formulas I and II: wherein X1-8 are each halogen and R1-8 are each independently halogen or an anti-stacking moiety; and [MxLySz]Cw (II) wherein M is a metal, L is an anion of a phthalocyanine compound of formula I as defined above, S is an organic or inorganic ligand, C is a counterion, x and y are numbers greater than zero, and z and w are numbers zero or greater, are disclosed. Pharmaceutical compositions comprising the compounds and methods of using the compounds, for example for treatment of cancer, are also disclosed.
Claims70
A phthalocyanine compound of formula I:
- [MxLySz]Cw (I)
- wherein:
- M is a metal;
- L is an anion of a phthalocyanine compound of formula II:
- wherein:
- X1-8 are each halogen;
- and
- R1-8 are each independently halogen or a perhalogenated anti-stacking moiety, provided that R1-8 are not all halogen;
- S is an organic or inorganic ligand;
- C is a counterion;
- x and y are each one;
- and
- z and w are numbers zero or greater, selected such that said phthalocyanine compound is electrically neutral.
A phthalocyanine compound of formula I:
- [MxLySz]Cw I
- wherein:
- M is a metal;
- L is an anion of a phthalocyanine compound of formula II
- wherein:
- X1-8 are each halogen;
- and
- R1-8 are each independently halogen or a perhalogenated anti-stacking moiety,
- provided that R1-8 are not all halogen;
- S is an organic or inorganic ligand;
- C is a counterion;
- x and y are each one;
- and
- z and w are numbers zero or greater, selected such that said phthalocyanine compound is electrically neutral;
- said compound having been prepared by a process comprising heating a phthalonitrile and a metal under conditions such that said compound is formed.
A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an effective amount of a phthalocyanine compound of formula I:
- [MxLySz]Cw I
- wherein:
- M is a metal;
- L is an anion of a phthalocyanine compound of formula II
- wherein:
- X1-8 are each halogen;
- and
- R1-8 are each independently halogen or a perhalogenated anti-stacking moiety, provided that R1-8 are not all halogen;
- S is an organic or inorganic ligand;
- C is a counterion;
- x and y are each one;
- and
- z and w are numbers zero or greater, selected such that said phthalocyanine compound is electrically neutral, and pharmaceutically acceptable salts thereof.
A phthalocyanines compound of formula (1):
- [MxLySz]Cw (I)
- wherein:
- M is a metal;
- L is an anion of a phthalocyanine compound of formula II:
- wherein:
- X1-8 are each halogen;
- and
- R1-8 are each independently halogen or a perhalogenated alkyl, provided that R1-8 are not all halogen;
- S is an organic or inorganic ligand, selected from group consisting of acetone, pyridine, methanol, DMF, THF, water, ethanol, propanol, CO,
- CO2 and SO2;
- C is a counterion;
- x and y are each independently one or two,
- z is zero, one or two;
- and
- w is zero.
Dependencies are inferred from the claim text.