Loading patent…
AssigneesThe University of Melbourne, Victorian Dairy Industry Authority
InventorsEric Charles Reynolds, Peter Singh Bhogal, Nada Slakeski
Estimating the term…
This invention relates to the PrtR-PrtK cell surface protein of Porphyromonas gingivalis in particular a multimeric cell associated protein complex comprising the PrtR and PrtK proteins. There is provided a substantially purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis. The complex comprises at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesin domain. The complex has a molecular weight of greater than about 200 kDa. The invention also relates to pharmaceutical compositions and associated agents based on said complex for the detection, prevention and treatment of Periodontal disease associated with P. gingivalis.
A purified antigenic complex for use in raising an antibody response directed against Porphyromonas gingivalis, the complex comprising at least one multimeric protein complex of arginine-specific and lysine-specific thiol endopeptidases each containing at least one adhesion domain, the complex having a molecular weight of about 294 to about 323 kDa wherein the multimeric protein complex comprises 9 proteins, the 9 proteins having the following N-terminal sequences:
Dependencies are inferred from the claim text.