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US 6,509,145 B1Granted
Process for reducing mineralization of tissue used in transplantation
AssigneeMedtronic, Inc.
InventorMark W. Torrianni
Life of this patent
Estimating the term…
Abstract
A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical device.
Claims57
A method of making a tissue-derived, implantable vascular bioprosthesis, the method comprising:
- excising tissue from an animal, the excised tissue selected form the group consisting of porcine aortic toot tissue, bovine aortic root tissue, porcine pericardium, bovine pericardium, bovine veins, porcine veins, bovine arteries, and porcine arteries;
- and removing cell debris from the excised tissue by a method which comprises:
- contacting the excised tissue with a composition comprising at least on oxidizing agent prior to significant degradation of the excised tissue;
- and rinsing the oxidizing agent-contacted tissue to remove at least a portion of the oxidizing agent, wherein the oxidizing agent is selected from the group of sodium hypochlorite, performic acid, periodic acid, peracetic acid, and combinations thereof.
1 more element
A method for making a tissue-derived implantable medical device from freshly excised tissue of an animal, the method comprising:
- excising fresh tissue from an animal, the tissue selected from the group consisting porcine aortic root tissue, bovine aortic root tissue, porcine pericardium, bovine pericardium, bovine veins, porcine veins, bovine arteries, and porcine arteries;
- contacting the freshly excised tissue with a composition comprising at least one oxidizing agent prior to significant degradation of the excised tissue, wherein the oxidizing agent is selected from the group of sodium hypochlorite, performic acid, periodic acid, peracetic acid, and combinations thereof;
- rinsing the oxidizing agent-contacted tissue to remove at least a portion of the oxidizing agent;
- and
- contacting the rinsed tissue with a composition comprising at least one reducing agent.
2 more elements
A method of making a tissue-derived heart valve bioprosthesis, the method comprising:
- excising heart valve tissue from an animal, the excised tissue including valvular leaflets and supporting structure;
- and
- removing cell debris from the excised tissue by a method which comprises:
- contacting the excised tissue with a composition comprising at least one oxidizing agent prior to significant degradation of the excised tissue;
- and rinsing the oxidizing agent-contacted tissue to remove at least a portion of the oxidizing agent, wherein the oxidizing agent is selected from the group of sodium hypochlorite, performic acid, periodic acid, peracetic acid, and combinations thereof.
2 more elements
Dependencies are inferred from the claim text.