4-dedimethylaminotetracycline derivatives
OwnerRobert A. Ashley, Joseph J. Hlavkainventors
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Abstract
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted at the 7, 8, and/or 9 positions and methods for preparing the 4-dedimethylamino tetracycline compounds. Other tetracycline compounds are the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N—NH-Alkyl group at the C4 position. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified 4-dedimethylamino tetracycline compounds.
Claims10
A 4-dedimethylaminotetracycline compound having structure P
- wherein:
- R8 is hydrogen and R9 is nitro (COL-1002).
Dependencies are inferred from the claim text.