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US 6,506,550 B1Granted
Method of including apoptosis by reducing the level of thiamin
AssigneeBrandeis University
InventorsChandler Fulton, Elaine Y. Lai
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Abstract
The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.
Claims9
A method for identifying a thiamin-depleting agent able to induce apoptosis of a vertebrate cell comprising providing a vertebrate cell;
- providing at least one compound having an anti-thiamin activity;
- contacting said cell with said at least one compound for a time sufficient to induce apoptosis of said cell by thiamin depletion;
- and
- observing whether apoptosis of said cell occurs, wherein said induction is indicative that said compound is a said thiamin-depleting agent able to induce apoptosis of a vertebrate cell.
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