Non-invasive tissue glucose level monitoring

A disposable non-invasive glucose monitoring instrument comprising:

• a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein said target is a tissue component;
• a radiation detector positioned to receive fluorescent radiation emitted from an excited target;
• and
• a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.

A non-invasive method of detecting a glucose level comprising:

• exciting a non-glucose target wherein the excited target is indicative of a glucose level of a patient and said target is a tissue component;
• detecting an amount of fluorescent radiation emitted by the target;
• and
• determining said glucose level from the amount of radiation detected.

A non-invasive glucose monitoring instrument comprising:

• an ultraviolet light source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient;
• a radiation detector positioned to receive radiation emitted from an excited target;
• and
• a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.

A non-invasive glucose monitoring instrument comprising:

• a radiation source capable of directing radiation to a portion of a tissue surface of a body wherein said source emits radiation at a wavelength that excites a target such that the excited target provides a glucose level indication of the patient wherein the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof;
• a radiation detector positioned to receive radiation emitted from an excited target;
• and
• a processing circuit operatively connected to the radiation detector that translates emitted radiation to a measurable signal to obtain said glucose level indication.

A non-invasive method of detecting a glucose level comprising:

• exciting a non-glucose target with an ultraviolet light source wherein the excited target is indicative of a glucose level of a patient;
• detecting an amount of radiation emitted by the target;
• and
• determining said glucose level from the amount of radiation detected.

A non-invasive method of detecting a glucose level comprising:

• exciting a non-glucose target wherein the excited target is indicative of a glucose level of a patient and the target is selected from the group consisting of a structural matrix component, a dermal matrix component, an epidermal matrix component, collagen, glycated collagen, glycosaminoglycans, elastin, glycosylated substances in a tissue, a pepsin-digestible cross link, a collagenase-digestible cross link, tryptophan and combinations thereof;
• detecting an amount of radiation emitted by the target;
• and
• determining said glucose level from the amount of radiation detected.

A non-invasive method of detecting a glucose level of a patient comprising:

• exciting a fluorophore in vivo with electromagnetic radiation wherein the excited fluorophore provides an indication of said glucose level;
• detecting an amount of radiation emitted by the fluorophore;
• and
• determining said glucose level from the amount of radiation detected.