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US 6,503,545 B1Granted
Hyper-absorption of vitamin E combined with milk protein
AssigneeBrandeis University
InventorsDaniel Perlman, Kenneth C. Hayes
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AssigneeBrandeis University
InventorsDaniel Perlman, Kenneth C. Hayes
Estimating the term…
A milk product providing an individual at least 31 IU (International Units) of vitamin E per serving, or an ingestible blend of at least one mammalian milk protein or fragment thereof, and vitamin E or other fat-soluble micronutrient or pharmacological agent is described. The vitamin E is uniformly microdispersed throughout the milk product, and ingestion of at least 100 IU of vitamin E per day in the product is sufficient to cause the fasting plasma vitamin E/cholesterol ratio in human subjects to be elevated at least 50% above the basal fasting level of vitamin E measured in the same subjects consuming no vitamin E dietary supplements. A method for elevating the plasma vitamin E level at least 50% in human subjects is also described. The method includes ingesting a milk product as described. A method for increasing the bioavailability of an orally administered fat-soluble micronutrient or pharmaceutical agent is also described. The method includes providing a microdispersed mixture of at least one fat-soluble micronutrient or pharmaceutical agent, and at least one mammalian milk protein or fragment thereof, in which the weight ratio of the milk protein to the micronutrient or pharmaceutical agent is between 1:1 and 1000:1.
A blended composition for oral administration to humans and other mammals, comprising a mixture of at least one mammalian milk protein or fragment thereof, and at least one fat-soluble vitamin, wherein said composition is a non-milk composition substantially free of lactose and milkfat, and wherein the weight ratio of said at least one mammalian milk protein or fragment thereof, to said at least one fat-soluble vitamin is between 1:1 and 100:1, wherein the gastrointestinal absorption of said fat-soluble vitamin is increased by ingesting said mixture rather than said fat-soluble vitamin alone.
A substantially lactose-free and milkfat-free composition for oral administration to a human or other mammal, comprising a microdispersed mixture of at least one mammalian milk protein or fragment thereof, and at least one fat-soluble micronutrient or pharmaceutical agent, wherein the weight ratio of said mammalian milk protein to said fat-soluble micronutrient or pharmaceutical agent is between 1:1 and 1000:1.
A method for increasing the bioavailability of an orally administered fat-soluble micronutrient or pharmaceutical agent consisting essentially of:
A blended composition for oral administration to humans and other mammals, comprising a mixture of at least one mammalian milk protein or fragment thereof, and at least one fat-soluble vitamin, wherein said composition is substantially free of lactose and milkfat, the weight ratio of said at least one mammalian milk protein or fragment thereof, to said at least one fat-soluble vitamin is between 1:1 and 1000:1, said mixture is a microdispersed mixture of said fat soluble vitamin and said at least one mammalian milk protein or fragment thereof, and the gastrointestinal absorption of said fat-soluble vitamin is increased by ingesting said mixture rather than said fat-soluble vitamin alone.
Dependencies are inferred from the claim text.