Back to results
US 6,503,538 B1Granted
Elastomeric functional biodegradable copolyester amides and copolyester urethanes
AssigneeCornell Research Foundation, Inc.
InventorsChih-Chang Chu, Ramaz Katsarava
Life of this patent
Estimating the term…
Abstract
The present invention provides elastomeric copolyester amides, elastomeric copolyester urethanes, and methods for making the same. The polymers that are based on α-amino acids and possess suitable physical, chemical and biodegradation properties. The polymers are useful as carriers of drugs or other bioactive substances.
Claims90
A polymer of formula (VII):
- wherein
- m is about 0.1 to about 0.9;
- p is about 0.9 to about 0.1;
- n is about 50 to about 150;
- each R1 is independently (C2-C20)alkyl;
- each R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl;
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- and
- each R4 is independently (C2-C20)alkyl.
6 more elements
A polymer of formula (VII) comprising one or more subunits of the formula (I):
- wherein
- R1 is independently (C2-C20)alkyl;
- and
- R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl;
- and one or more subunits of the formula (II):
- wherein
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- and
- R4 is independently (C2-C20)alkyl.
6 more elements
A polymer of formula (VII) formed from an amount of one or more compounds of formula (III):
- wherein
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- and
- R4 is independently (C2-C20)alkyl;
- or a suitable salt thereof;
- an amount of one or more compounds of formula (IV):
- wherein
- R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl;
- or a suitable salt thereof;
- and
- an amount of one or more compounds of formula (V):
- wherein
- R1 is independently (C2-C20)alkyl;
- and
- each R5 is independently (C6-C10)aryl optionally substituted with one or more nitro, cyano, halo, trifluoromethyl, or trifluoromethoxy.
12 more elements
A method for preparing a polymer of formula (VII):
- wherein
- m is about 0.1 to about 0.9;
- p is about 0.9 to about 0.1;
- n is about 50 to about 150;
- each R1 is independently (C2-C20)alkyl;
- each R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl;
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- and
- each R4 is independently (C2-C20)alkyl;
- comprising contacting an amount of one or more compounds of formula (III):
- or a suitable salt thereof;
- an amount of one or more compounds of formula (IV):
- or a suitable salt thereof;
- and
- an amount of one or more compounds of formula (V):
- wherein
- each R5 is independently (C6-C10)aryl optionally substituted with one or more nitro, cyano, halo, trifluoromethyl, or trifluoromethoxy;
- under suitable conditions to provide the polymer of formula (VII).
15 more elements
A polymer of formula (XI):
- wherein
- m is about 0.1 to about 0.9;
- p is about 0.9 to about 0.1;
- n is about 50 to about 150;
- each R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl;
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- each R4 is independently (C2-C20)alkyl;
- and
- each R6 is independently (C2-C20)alkyl or (C2-C8)alkyloxy(C2-C20)alkyl.
6 more elements
A polymer of formula (XI) comprising one or more subunits of the formula (VIII):
- wherein
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- and
- R4 is independently (C2-C20)alkyl;
- R6 is independently (C2-C20)alkyl or (C2-C8)alkyloxy(C2-C20)alkyl;
- and one or more subunits of the formula (IX):
- wherein
- R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl.
5 more elements
A polymer of formula (XI) formed from an amount of one or more compounds of formula (III):
- wherein
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- and
- R4 is independently (C2-C20)alkyl;
- or a suitable salt thereof;
- an amount of one or more compounds of formula (IV):
- wherein
- R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl;
- or a suitable salt thereof;
- and
- an amount of one or more compounds of formula (X):
- wherein
- each R5 is independently (C6-C10)aryl optionally substituted with one or more nitro, cyano, halo, trifluoromethyl, or trifluoromethoxy;
- and
- R6 is independently (C2-C20)alkyl or (C2-C8)alkyloxy(C2-C20)alkyl.
12 more elements
A method for preparing a polymer of formula (XI):
- wherein
- m is about 0.1 to about 0.9;
- p is about 0.9 to about 0.1;
- n is about 50 to about 150;
- each R2 is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl;
- each R3 is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl;
- each R4 is independently (C2-C20)alkyl;
- each R5 is independently (C6-C10)aryl optionally substituted with one or more nitro, cyano, halo, trifluoromethyl, or trifluoromethoxy;
- and
- each R6 is independently (C2-C20)alkyl or (C2-C8)alkyloxy(C2-C20)alkyl;
- comprising contacting an amount of one or more compounds of formula (III):
- or a suitable salt thereof;
- an amount of one or more compounds of formula (IV):
- or a suitable salt thereof;
- and
- an amount of one or more compounds of formula (X):
- under suitable conditions to provide the polymer of formula (XI).
14 more elements
Dependencies are inferred from the claim text.