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US 6,503,450 B1Granted
Integrated blood oxygenator and pump system
AssigneeCardiovention, Inc.
InventorsThomas A. Afzal, Jean-Pierre Dueri, Alex Leynov, Anthony Makarewicz, Alec A. Piplani, Greg Potts
Life of this patent
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Abstract
Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. An inner member arranged along a central axis of the device accelerates blood entering the fiber bundle to reduce microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to reduce flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements.
Claims42
A system for processing blood comprising:
- a housing having a gas inlet, a gas outlet, a blood inlet and a blood outlet;
- a fiber bundle disposed for rotation within the housing, the fiber bundle having a central void in fluid communication with the blood inlet;
- and
- an inner member disposed within the central void, the inner member being rotatable relative to the housing, the inner member having a length and being tapered along the length.
1 more element
A method for processing blood comprising:
- providing a device including a housing having a gas inlet, a gas outlet, a blood inlet, a blood outlet, a gas transfer element disposed for rotation within the housing, the gas transfer element having a first end, a second end, a central void, and an inner member disposed within the central void, the first end coupled to the gas inlet and the second end coupled to the gas outlet, the inner member having first and second inner member ends and being tapered from the first inner member end to the second inner member end;
- flowing blood into the housing so that the blood enters the central void;
- delivering a gas comprising oxygen to the gas transfer element so that at least oxygen is transferred to the blood passing through the device;
- rotating the inner member to cause blood to flow outward from the central void into the gas transfer element;
- and
- rotating the gas transfer element to oxygenate blood flowing through the housing.
3 more elements
A method for processing blood comprising:
- providing a device including a housing having a gas inlet, a gas outlet, a blood inlet, a blood outlet, a gas transfer element disposed for rotation within the housing, the gas transfer element having a first end, a second end, a central void, the first end coupled to the gas inlet and the second end coupled to the gas outlet, and a pumping element positioned to receive the blood from the blood inlet prior to entry into the central void;
- flowing blood into the housing so that the blood enters the pumping element;
- rotating the pumping element to accelerate and deliver the blood into the central void;
- delivering a gas comprising oxygen to the gas transfer element so that at least oxygen is transferred to the blood passing through the device;
- rotating the gas transfer element to cause blood to flow outward from the central void into the gas transfer element and oxygenate blood flowing through the housing.
2 more elements
A system for processing blood comprising:
- a housing having a gas inlet, a gas outlet, a blood inlet and a blood outlet;
- a fiber bundle disposed for rotation within the housing, the fiber bundle having a central void in fluid communication with the blood inlet;
- a girdle disposed about an exterior surface of the fiber bundle;
- and
- an inner member disposed within the central void, the inner member being rotatable relative to the housing.
2 more elements
A system for processing blood comprising:
- a housing having a gas inlet, a gas outlet, a blood inlet and a blood outlet;
- a fiber bundle disposed for rotation within the housing, the fiber bundle having a central void in fluid communication with the blood inlet;
- a gas manifold coupled to the fiber bundle;
- a baffle plate disposed within the gas manifold and adapted to urge blood in the gas manifold that has leaked from the fiber bundle to exit the housing via the gas outlet;
- and
- an inner member disposed within the central void, the inner member being rotatable relative to the housing.
3 more elements
A method for processing blood comprising:
- providing a device including a housing having a gas inlet, a gas outlet, a blood inlet, a blood outlet, a gas transfer element disposed for rotation within the housing, the gas transfer element having a first end, a second end, a plurality of fibers, means for reducing outward bowing of the fibers, a central void, and an inner member disposed within the central void, the first end coupled to the gas inlet and the second end coupled to the gas outlet;
- flowing blood into the housing so that the blood enters the central void;
- delivering a gas comprising oxygen to the gas transfer element so that at least oxygen is transferred to the blood passing through the device;
- rotating the inner member to cause blood to flow outward from the central void into the gas transfer element;
- and
- rotating the gas transfer element to oxygenate blood flowing through the housing.
3 more elements
Dependencies are inferred from the claim text.