13-substituted methacycline compounds
AssigneesParatek Pharmaceuticals, Inc., Trustees of Tufts College
InventorsMark L. Nelson, Beena Bhatia, Laura McIntyre, Glen Rennie
Life of this patent
Estimating the term…
Abstract
13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
Claims30
A 13-substituted methacycline compound of the formula:
- wherein:
- R4 and R4′ are each alkyl;
- R5 is hydrogen, hydroxyl, or a prodrug moiety;
- R6 is a phenyl group, an alkoxyphenyl group, a halophenyl group, a carboxyphenyl group, an acylphenyl group, a cyanophenyl group, a nitrophenyl group, a naphthyl group, a dialkylphenyl group or an alkylphenyl group;
- a t-butyl group;
- or an aminoalkanethio group;
- and pharmaceutically acceptable salts thereof.
A 13-substituted methacycline compound, wherein said compound is 9,13-(di-t-butyl) methacycline.
A method for synthesisizing a 13-substituted methacycline compound, comprising contacting a methacycline compound with a boronic acid, under appropriate conditions such that a 13-substituted methacycline compound is formed.
A method for synthesizing a 13-substituted methacycline compound, comprising contacting a methacycline compound with a tertiary alcohol, under appropriate conditions such that a 13-substituted methacycline compound is synthesized.
Dependencies are inferred from the claim text.