Compounds
AssigneeSmithKline Beecham Corporation
InventorNicola Gail Wallis
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Abstract
The invention provides histidine kinase polypeptides and DNA (RNA) encoding histidine kinase polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidine kinase polypeptides to screen for antibacterial compounds.
Claims14
An isolated polypeptide comprising SEQ ID NO:2.
An isolated fusion polypeptide comprising a heterologous amino acid sequence fused to SEQ ID NO:2.
An isolated polypeptide comprising at least 50 consecutive amino acids of SEQ ID NO:
- 2, wherein said polypeptide is capable of functioning as a histidine kinase.
An isolated fusion polypeptide comprising a heterologous amino acid sequence fused to at least 50 consecutive amino acids of SEQ ID NO:
- 2, wherein said polypeptide is capable of functioning as a histidine kinase.
An isolated polypeptide comprising at least 30 consecutive amino acids of SEQ ID NO:
- 2, wherein said polypeptide is capable of functioning as a histidine kinase.
An isolated fusion polypeptide comprising a heterologous amino acid sequence fused to at least 50 consecutive amino acids of SEQ ID NO:
- 2, wherein said polypeptide is capable of functioning as a histidine kinase.
Dependencies are inferred from the claim text.