Lecithin-cholesterol acyltransferase protein
AssigneeTakeda Chemical Industries, Ltd.
InventorYoshio Taniyama
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AssigneeTakeda Chemical Industries, Ltd.
InventorYoshio Taniyama
Estimating the term…
This invention relates to a novel protein having a lecithin-cholesterol acyltransferase-like activity, etc. or its salt, a precursor protein of the protein or its salt, a partial peptide of the protein or its salt; a DNA coding for the protein; a recombinant vector; a transformant; a method for producing the protein, a pharmaceutical composition comprising the protein, the partial peptide or its salt; and an antibody to the protein or the partial peptide. The protein, the partial peptide or its salt, and the DNA are useful as an agent for treating or preventing arteriosclerosis, atherosclerosis, hyperlipidemia, hypercalorism, obesity or hypertriglyceridemia. The antibody can be used in assay of the protein, the partial peptide or its salt. The protein, the partial peptide or its salt is useful as a reagent for the screening for candidate medical compounds.
An isolated protein comprising an amino acid sequence represented by SEQ ID NO:1, a precursor protein thereof or a salt thereof.
An isolated peptide which comprises at least one amino acid sequence selected from the group consisting of amino acid sequences of the 3rd-25th residues, 27th-36th residues, 43rd-66th residues, 68th-86th residues, 92nd-98th residues,107th-153rd residues, 155th-168th residues, 172nd-180th residues, 189th-240th residues, 256th-262nd residues, 268th-275th residues, 277th-287th residues, 295th-306th residues, 308th-332nd residues, 336th-347th residues and/or 351st-377th residues of the amino acid sequence represented by SEQ ID NO:1.
Dependencies are inferred from the claim text.