Methods of treatment of disease using adsorbent carriers
AssigneeJapan Immunoresearch Laboratories Co., Ltd.
InventorsMasakazu Adachi, Toshifumi Hibi
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Abstract
The invention relates to a method for the removal of leucocytes from blood which comprises bringing blood that comprises infected leucocytes into contact with an adsorbent carrier that has a greater affinity for infected, activated and/or defective leucocytes than for uninfected leucocytes especially cellulose acetate. The method can be used in the apheresis treatment of diseases caused by pathogenic organisms, for example, HIV, HCV or malaria. It is especially useful for treatment of HIV.
Claims36
A method of treatment of a subject infected with a pathogenic organism comprising contacting blood from said subject with an adsorbent carrier whereby infected, activated or defective lymphocytes are adsorbed, and returning activated or defective lymphocytes are adsorbed, and returning the resulting blood to said subject, wherein said adsorbent carrier has a contact angle to water of from 55° to 95°.
A method of treatment of a subject afflicted with a disease or disorder in which lymphocytes are infected, activated or defective comprising contacting blood from said subject with an adsorbent carrier and returning the resulting blood to said subject, wherein said adsorbent carrier has a greater affinity for infected, activated or defective lymphocytes than for uninfected, non-activated or non-defective lymphocytes, respectively, so as to remove said infected, activated or defective lymphocytes from said blood.
Dependencies are inferred from the claim text.