Resorbable matrices for delivery of bioactive compounds
AssigneeRoyer Biomedical, Inc.
InventorGarfield P. Royer
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Abstract
This invention relates generally to the production and use of inorganic-conditioning agent complexes for the controlled release of compounds including medicinals. Advantageously, the inorganic used is calcium sulfate and the conditioning agent is calcium stearate.
Claims55
A matrix delivery system comprising:
- a) calcium sulfate, and
- b) a conditioning agent, wherein
- said calcium sulfate of said matrix delivery system becomes a solid by hydration, and wherein
- said conditioning agent is present in the range of 5-30% (w/w). based on calcium sulfate.
A composition comprising amikacin sulfate and amikacin pamoate.
A method of producing a delivery system comprising mixing (a) calcium sulfate, (b) a matrix biopolymer, and (c) a conditioning agent, wherein said conditioning agent is present in the range of 5-30% (w/w) based on calcium sulfate.
A method for administering a delivery system comprising:
- (a) mixing calcium sulfate, a conditioning agent in the range of 5-30% (w/w) based on calcium sulfate, and a medicinal to form a slurry;
- b) administering said slurry to said mammal, wherein
- said slurry solidifies after administration.
An antibiotic selected from the group consisting of amikacin pamoate, clindamycin pamoate and gentamicin pamoate.
A method of producing a delivery system comprising mixing:
- a) an inorganic compound capable of undergoing hydration and/or crystallization, a conditioning agent and thrombin,
- b) fibrinogen,
- wherein mixing (a) and (b) converts fibrinogen to fibrin.
Dependencies are inferred from the claim text.